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Unfolded protein response pathway in leishmaniasis: A review

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dc.contributor.author Edirisinghe, N.M.
dc.contributor.author Manamperi, N.H.
dc.contributor.author Wanasinghe, V.S.
dc.contributor.author Karunaweera, N.
dc.date.accessioned 2023-08-17T04:46:36Z
dc.date.available 2023-08-17T04:46:36Z
dc.date.issued 2023
dc.identifier.citation Parasite Immunology.2023 : e13009 (Online ahead of print.) en_US
dc.identifier.issn 0141-9838 (Print)
dc.identifier.issn 1365-3024 (Electronic)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/26499
dc.description Indexed in MEDLINE en_US
dc.description.abstract Alteration in the physiological state of the endoplasmic reticulum (ER) leads to the specific response known as unfolded protein response (UPR) or ER stress response. The UPR is driven by three sensor proteins, namely: Inositol-Requiring Enzyme 1, Protein Kinase RNA-like ER kinase and Activating Transcription Factor 6 to restore ER homeostasis. Pathogenic infection can initiate UPR activation; some pathogens can subvert the UPR to promote their survival and replication. Many intracellular pathogens, including Leishmania, can interact and hijack ER for their survival and replication, triggering ER stress and subsequently ER stress response. This review aims to provide a comprehensive overview of the ER stress response in infections with the Leishmania species. en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.subject Leishmania species en_US
dc.subject activating transcription factor 6 en_US
dc.subject endoplasmic reticulum en_US
dc.subject inositol requiring enzyme 1 en_US
dc.subject leishmaniasis en_US
dc.subject protein kinase RNA-like ER kinase en_US
dc.subject unfolded protein response en_US
dc.title Unfolded protein response pathway in leishmaniasis: A review en_US
dc.type Article en_US


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