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Myocardial infarction in patients with severe beta thalassaemia: A case series

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dc.contributor.author Premawardhena, A.
dc.contributor.author de Silva, S.
dc.contributor.author Rajapaksha, M.
dc.contributor.author Ratnamalala, V.
dc.contributor.author Nallarajah, J.
dc.contributor.author Galappatthy, G.
dc.date.accessioned 2023-03-13T08:51:06Z
dc.date.available 2023-03-13T08:51:06Z
dc.date.issued 2023
dc.identifier.citation International Journal of Emergency Medicine.2023;16(1):16. en_US
dc.identifier.issn 1865-1372
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/26025
dc.description indexed in MEDLINE & SCOPUS en_US
dc.description.abstract BACKGROUND: Cardiac disease remains a dominant if not the most important cause of morbidity and mortality in patients with thalassaemia, particularly in those with thalassaemia major. Myocardial infarction and coronary artery disease however are rarely reported. CASE PRESENTATIONS: Three older patients with three distinct thalassaemia syndromes presented with acute coronary syndrome. Two were heavily transfused whilst the other was a minimally transfused patient. Both heavily transfused patients had ST-elevation myocardial infarctions (STEMI) while the minimally transfused patient had unstable angina. Coronary angiogram (CA) was normal in two patients. One patient who developed a STEMI had a 50% plaque. All three were managed as standard ACS, although the aetiology appeared non-atherogenic. CONCLUSIONS: The exact etiology of the presentation, remains a mystery and therefore the rational use of thrombolytic therapy, carrying out angiogram in the primary setting, using and continuing antiplatelet and high dose statins all remains unclear in this sub group of patients. en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.subject Myocardial infarction en_US
dc.subject Beta thalassaemia en_US
dc.title Myocardial infarction in patients with severe beta thalassaemia: A case series en_US
dc.type Article en_US


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