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Early life events in functional abdominal pain disorders in children

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dc.contributor.author Karunanayake, A.
dc.contributor.author Devanarayana, N.M.
dc.contributor.author Rajindrajith, S.
dc.date.accessioned 2022-11-08T06:43:45Z
dc.date.available 2022-11-08T06:43:45Z
dc.date.issued 2022
dc.identifier.citation PLoS One.2022;17(11):e0275419. en_US
dc.identifier.issn 1932-6203
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/25575
dc.description Indexed in MEDLINE. en_US
dc.description.abstract Objectives: Functional abdominal pain disorders (FAPDs) are common gastrointestinal problems in children, and the pathophysiology is thought to be multifactorial. Adverse early life events (ELE) induce alterations in the central nervous system, perhaps predisposing individuals to develop FAPDs. We aimed to study the potential adverse ELE that are associated with FAPDs. Methods: We steered a school-based survey involving 1000 children from 4 randomly selected schools. FAPDs were assessed using the translated Rome III questionnaire, and ELE were identified using a pre-tested, parental questionnaire. FAPDs were diagnosed using the Rome III criteria. Results: Hundred and eighty-two (182) children had FAPDs (62.1% girls, mean age 8.5, SD 2.1). ELE of them were compared with 571 children without FAPDs (51.1% girls, mean age 8.8, SD 1.9). According to the binary logistic regression analysis, family members with abdominal pain, family member with chronic pain other than abdominal pain, prenatal maternal complications and interventional deliveries, were recognized as potential risk factors for the development of FAPDs. Breast feeding over two years has shown to reduce the prevalence of FAPDs.a. Conclusions: Prenatal maternal medical problems are associated a with higher prevalence of FAPDs later in life. Prolonged breastfeeding and normal vaginal delivery could be considered as factors that reduce the vulnerability of developing FAPDs in children. Therefore, minimizing pregnancy-related complications, encouraging vaginal deliveries, and encouraging breastfeeding are potentially valuable measures to prevent FAPDs during childhood. en_US
dc.language.iso en en_US
dc.publisher Public Library of Science,San Francisco en_US
dc.subject Abdominal en_US
dc.title Early life events in functional abdominal pain disorders in children en_US
dc.type Article en_US


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