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Composite carotid intima-media thickness as a risk predictor of coronary heart disease in a selected population in Sri Lanka

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dc.contributor.author Abeysuriya, V.
dc.contributor.author Wijesinha, N.A.I.
dc.contributor.author Priyadharshan, P.P.
dc.contributor.author Chandrasena, L.G.
dc.contributor.author Wickremasinghe, A.R.
dc.date.accessioned 2022-09-06T06:42:30Z
dc.date.available 2022-09-06T06:42:30Z
dc.date.issued 2022
dc.identifier.citation PLoS One.2022;17(8):e0271986. en_US
dc.identifier.issn 1932-6203
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/25155
dc.description Indexed in MEDLINE. en_US
dc.description.abstract Background: Segment-specific variations of carotid intima-media thickness (CIMT) have not been assessed in South Asian populations. The purpose of this study was to determine if segment-specific CIMTs or a composite-CIMT score is a better risk predictor of coronary heart disease in South Asian populations. Methods: A comparative prospective study was conducted from November 2019 to October 2020 in a hospital in Colombo, Sri Lanka. Based on pre-defined inclusion and exclusion criteria, cases (having a diagnosis of Coronary Heart Disease (CHD), n = 338) and controls (non-CHD group, n = 356) were recruited. Ultrasound examination of the common carotid (CCA), the carotid bulb (CB) and the internal carotid segments (ICA) of the carotid vessels was conducted by a radiologist, and CIMTs were measured. A composite-CIMT score defined as the average value of all six segments of the left and right sides was derived. Results: 694 participants were enrolled (male n = 399, 57.5%). The mean (±SD) age of the study sample was 60.2 (±9.86) years. There were variations in segment-specific values between the left and right vessels. The mean composite-CIMT value of the CHD group was significantly higher than that of the non-CHD group. A composite-CIMT score of 0.758 had a sensitivity of 98.4% and a specificity of 64.6% in distinguishing CHD from non-CHD groups (Area under the curve (AUC): 0.926). Conclusions: Carotid artery segment-specific CIMT variations were present in this population. The composite CIMT score is better than segment-specific CIMTs in predicting CHD and may be used to predict CHD in this population. en_US
dc.language.iso en en_US
dc.publisher Public Library of Science, en_US
dc.subject coronary heart en_US
dc.title Composite carotid intima-media thickness as a risk predictor of coronary heart disease in a selected population in Sri Lanka en_US
dc.type Article en_US


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