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Thinness negatively affects lung function among Sri Lankan children

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dc.contributor.author Senevirathna, N.
dc.contributor.author Amarasiri, L.
dc.contributor.author Jayamanne, D.
dc.contributor.author Manel, K.
dc.contributor.author Liyanage, G.
dc.date.accessioned 2022-08-16T06:58:29Z
dc.date.available 2022-08-16T06:58:29Z
dc.date.issued 2022
dc.identifier.citation PLoS One.2022;17(8):e0272096. en_US
dc.identifier.issn 1932-6203
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/25077
dc.description indexed in MEDLINE. en_US
dc.description.abstract Background: There have been conflicting findings on the effect of body mass index (BMI) on lung functions in children. Therefore, we studied the relationship between spirometry parameters and BMI among healthy Sri Lankan school children aged 5-7 years. Methods: A cross-sectional study was conducted among 296 school children (5-7-year-old) without apparent lung disease. Recruitment was done with stratified random sampling. Spirometry parameters, FEV1, FVC, PEFR, and FEV1/FVC ratio were determined. The acceptable and reproducible spirometry recordings were included in the analysis. Simple and multivariate linear regression analysis examined possible associations of lung function parameters with BMI, socio-demographic variables and indoor risk factors. Also, the mediator effect of gender on lung function through BMI was explored. Results: The participants' mean age (SD) was 6.4 (0.65) years. One-third were thin/severely thin (37%). A statistically significant difference in FVC (p = 0.001) and FEV1 (p = 0.001) was observed between BMI groups (obesity/overweight, normal, and thinness). Yet, PEFR or FEV1/FVC did not significantly differ among BMI groups (p = 0.23 and p = 0.84). Multivariate regression analysis showed that FEV1 and FVC were significantly associated with BMI, child's age, gender, family income, father's education, having a pet, and exposure to mosquito coil smoke. Interaction between gender and BMI for lung functions was not significant. The thin children had significantly lower FVC (OR: -0.04, 95%CI: -0.077, -0.012, p = 0.008) and FEV1 (OR: -0.04, 95%CI: -0.075, -0.014, p = 0.004) than normal/overweight/obese children. Family income demonstrated the greatest effect on lung functions; FVC and FEV1 were 0.25L and 0.23L smaller in low-income than the high-income families. Conclusion: Lower lung function parameters (FVC and FEV1) are associated with thinness than normal/overweight/obese dimensions among children without apparent lung disease. It informs that appropriate nutritional intervention may play a role in improving respiratory health. en_US
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.subject children en_US
dc.subject lung function en_US
dc.title Thinness negatively affects lung function among Sri Lankan children en_US
dc.type Article en_US


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