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Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis

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dc.contributor.author Hemady, C.L.
dc.contributor.author Speyer, L.G.
dc.contributor.author Murray, A.L.
dc.contributor.author Brown, R.H.
dc.contributor.author Meinck, F.
dc.contributor.author Fry, D.
dc.contributor.author Do, H.
dc.contributor.author Sikander, S.
dc.contributor.author Madrid, B.
dc.contributor.author Fernando, A.
dc.contributor.author Walker, S.
dc.contributor.author Dunne, M.
dc.contributor.author Foley, S.
dc.contributor.author Hughes, C.
dc.contributor.author Osafo, J.
dc.contributor.author Baban, A.
dc.contributor.author Taut, D.
dc.contributor.author Ward, C.L.
dc.contributor.author Thang, V.V.
dc.contributor.author Fearon, P.
dc.contributor.author Tomlinson, M.
dc.contributor.author Valdebenito, S.
dc.contributor.author Eisner, M.
dc.date.accessioned 2022-06-28T03:08:49Z
dc.date.available 2022-06-28T03:08:49Z
dc.date.issued 2022
dc.identifier.citation BMC Pregnancy and Childbirth.2022;22(1):505. en_US
dc.identifier.issn 1471-2393
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/24928
dc.description indexed in MEDLINE. en_US
dc.description.abstract Background: This paper enumerates and characterizes latent classes of adverse childhood experiences and investigates how they relate to prenatal substance use (i.e., smoking, alcohol, and other drugs) and poor infant outcomes (i.e., infant prematurity and low birthweight) across eight low- and middle-income countries (LMICs). Methods: A total of 1189 mother-infant dyads from the Evidence for Better Lives Study cohort were recruited. Latent class analysis using the Bolck, Croon, and Hagenaars (BCH) 3-step method with auxiliary multilevel logistic regressions was performed. Results: Three high-risk classes and one low-risk class emerged: (1) highly maltreated (7%, n = 89), (2) emotionally and physically abused with intra-familial violence exposure (13%, n = 152), (3), emotionally abused (40%, n = 474), and (4) low household dysfunction and abuse (40%, n = 474). Pairwise comparisons between classes indicate higher probabilities of prenatal drug use in the highly maltreated and emotionally abused classes compared with the low household dysfunction and abuse class. Additionally, the emotionally and physically abused with intra-familial violence exposure class had higher probability of low birthweight than the three remaining classes.Conclusion: Our results highlight the multifaceted nature of ACEs and underline the potential importance of exposure to childhood adversities on behaviors and outcomes in the perinatal period. This can inform the design of antenatal support to better address these challenges. en_US
dc.language.iso en en_US
dc.publisher BioMed Central,London en_US
dc.subject Adverse childhood experiences en_US
dc.subject Intergenerational transmission of adversity en_US
dc.subject Latent class analysis en_US
dc.title Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis en_US
dc.type Article en_US


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