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Molecular characterization of rickettsial agents in ticks (Acari: Ixodidae) from Sri Lanka

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dc.contributor.author Dasch, G.A.
dc.contributor.author Eremeeva, M.E.
dc.contributor.author Zambrano, M.L.
dc.contributor.author Premaratna, R.
dc.contributor.author Kularatne, S.A.M.
dc.contributor.author Rajapakse, R.P.V.J.
dc.date.accessioned 2022-04-19T04:59:56Z
dc.date.available 2022-04-19T04:59:56Z
dc.date.issued 2022
dc.identifier.citation American Journal of Tropical Medicine and Hygiene.2022;106 (6):1613-1623. en_US
dc.identifier.issn 0002-9637
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/24561
dc.description Indexed in MEDLINE. en_US
dc.description.abstract Because the majority of spotted fever group rickettsiae are transmitted to humans by tick bites, it is important to understand which ticks might play a role in transmission of rickettsial pathogens in Sri Lanka. The purpose of our study was to conduct molecular surveillance of 847 ticks collected in different locations in central Sri Lanka to determine which were infected with Rickettsia and Anaplasmataceae. Molecular methods were used to identify the ticks and the agents detected. Most ticks (Amblyomma, Haemaphysalis, and Rhipicephalus) were collected by flagging, and lower number was collected from dogs, cattle, pigs, a pangolin, and tortoises. Five spotted fever genotypes were identified: a Rickettsia africae-like agent in Amblyomma larvae, Rhipicephalus massiliae and a related genotype identified in association with the tropical type of Rhipicephalus sanguineus from dogs and Rhipicephalus haemaphysaloides from dogs and cattle, and Candidatus R. kellyi and another novel genotype (SL94) in R. haemaphysaloides. Twenty-three ticks were positive for Anaplasmataceae, including one Anaplasma and two Ehrlichia genotypes. Because the sequence database for both ticks and rickettsial agents from Sri Lanka and southern India is not extensive, additional molecular characterization of the tick species of Sri Lanka and their rickettsial agents is required to understand their pathogenic potential more completely. However, several of the agents we identified in this survey may well be pathogenic for humans and domestic animals, and should be considered as a part of epidemiological surveillance and patient management. en_US
dc.language.iso en en_US
dc.publisher Baltimore. en_US
dc.subject Molecular en_US
dc.title Molecular characterization of rickettsial agents in ticks (Acari: Ixodidae) from Sri Lanka en_US
dc.type Article en_US


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