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Survival pattern and clinicopathological data from a South Asian cohort of young colorectal cancers treated with curative intent

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dc.contributor.author Gunasekare, K.
dc.contributor.author Godahewa, S.
dc.contributor.author Vishwajith, P.
dc.contributor.author Gajasinghe, S.
dc.contributor.author Ekanayake, M.
dc.contributor.author Kumarage, S.
dc.contributor.author Chandrasinghe, P.
dc.date.accessioned 2022-01-15T14:03:33Z
dc.date.available 2022-01-15T14:03:33Z
dc.date.issued 2021
dc.identifier.citation Techniques in Coloproctology 2021 25(5):637 en_US
dc.identifier.issn 1123-6337 (Print)
dc.identifier.issn 1128-045X (Electronic)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/24349
dc.description Presentation Abstracts, 14th European Colorectal Congress (ECCS) November 29-December 2, 2020, St.Gallen, Switzerland en_US
dc.description.abstract BACKGROUND/AIM :Colorectal cancer (CRC) has the fourth highest incidence among cancers in Sri Lanka. Although CRC is considered as a disease of the elderly, currently there is a shift towards an increasing incidence of young cancers globally. Despite the increasing incidence there is a scarcity of data from the South Asian region. This study aims to analyze the clinicopathological features and long term survival of young CRC from a South Asian cohort of patients. METHODS: All patients treated for CRC at a tertiary care center from 1997 to 2017 were prospectively followed up. Demographics, tumour characteristics and survival data were recorded. Age less than 45 years at diagnosis was considered as a young cancer. Overall survival among the populations was compared using Kaplan-Mire survival curves. A P value of\0.05 was considered significant. Results: A total of 113 (16.5%) young cancers (Mean age 36.35; range 17–45; female 53.1%) were operated during the period. Rectum (60.2%) was the commonest site followed by the right colon (24.8%) and left colonic (15%) tumors. Adenocarcinomas of moderately differentiated variety (72.4%) was the commonest histological type. Seventy percent of cases had locally advanced disease (T3/T4) with 53.2% having positive nodal status. Of the total 27% received neoadjuvant treatment and 66.7% received adjuvant treatment. Young CRC patients had a significantly better overall survival compared to their older counterparts (P = 0.008). CONCLUSION Young cancers accounts for a significant proportion of the colorectal cancers in this cohort. Over 75% of the cancers were on the left colon and the majority was locally advanced disease. Overall survival of the young CRCs were better compared to the older population in this cohort. en_US
dc.language.iso en_US en_US
dc.publisher Springer en_US
dc.subject Colorectal Neoplasms en_US
dc.subject Colorectal Neoplasms-pathology en_US
dc.subject Sri Lanka-epidemiology en_US
dc.subject Cohort Studies en_US
dc.title Survival pattern and clinicopathological data from a South Asian cohort of young colorectal cancers treated with curative intent en_US
dc.type Conference Abstract en_US


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