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Apoferritin and Dps as drug delivery vehicles: Some selected examples in oncology

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dc.contributor.author Kuruppu, A.I.
dc.contributor.author Turyanska, L.
dc.contributor.author Bradshaw, T.D.
dc.contributor.author Manickam, S.
dc.contributor.author Galhena, B.P.
dc.contributor.author Paranagama, P.
dc.contributor.author de Silva, R.
dc.date.accessioned 2022-01-13T07:04:48Z
dc.date.available 2022-01-13T07:04:48Z
dc.date.issued 2022
dc.identifier.citation Biochimica et Biophysica Acta. General Subjects. 2022;1866(2):130067 en_US
dc.identifier.issn 0304-4165 (Print)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/24339
dc.description Indexed in MEDLINE. en
dc.description.abstract Background: The ideal nanoparticle should be able to encapsulate either pharmaceutical agents or imaging probes so that it could treat or image clinical tumours by targeting the cancer site efficiently. Further, it would be an added advantage if it demonstrates: small size, built in targeting, biocompatibility and biodegradability. Ferritin, which is an endogenous self-assembling protein, stores iron and plays a role in iron homeostasis. When iron atoms are removed apoferritin (AFt) is formed which consists of a hollow shell where it can be used to load guest molecules. Due to its unique architecture, AFt has been investigated as a versatile carrier for tumour theranostic applications. DNA-binding protein from starved cells (Dps), which also belongs to the ferritin family, is a protein found only in prokaryotes. It is used to store iron and protect chromosomes from oxidative damage; because of its architecture, Dps could also be used as a delivery vehicle. Conclusions: Both these nano particles are promising in the field of oncology, especially due to their stability, solubility and biocompatibility features. Further their exterior surface can be modified for better tumour-targeting ability. More studies, are warranted to determine the immunogenicity, biodistribution, and clearance from the body. General perspective: This review discusses a few selected examples of the remarkable in vitro and in vivo studies that have been carried out in the recent past with the use of AFt and Dps in targeting and delivery of various pharmaceutical agents, natural products and imaging probes in the field of oncology. en_US
dc.language.iso en en_US
dc.publisher Elsevier Ltd en_US
dc.subject Apoferritins en_US
dc.subject Neoplasms en_US
dc.subject DNA-Binding Proteins en_US
dc.title Apoferritin and Dps as drug delivery vehicles: Some selected examples in oncology en_US
dc.type Article en_US


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