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Prevalence, predictors and outcome of chronic kidney disease in a cohort of aging urban, adult Sri Lankans

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dc.contributor.author de Silva, S.T.
dc.contributor.author Ediriweera, D.D.
dc.contributor.author Niriella, M.A.
dc.contributor.author Kasturiratne, A.
dc.contributor.author Kato, N.
dc.contributor.author Wickremasinghe, A.R.
dc.contributor.author de Silva, H.J.
dc.date.accessioned 2021-11-12T07:40:56Z
dc.date.available 2021-11-12T07:40:56Z
dc.date.issued 2021
dc.identifier.citation Sri Lanka Medical Association, 134th Anniversary International Medical Congress. 2021; 75-78 en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/23887
dc.description Oral Presentation Abstract (OP12), “Professional Excellence Towards Holistic Healthcare”, 134th Anniversary International Medical Congress, Sri Lanka Medical Association, 21st – 24th September 2021, Colombo, Sri Lanka en_US
dc.description.abstract Introduction and Objectives Chronic kidney disease (CKD) affects 700 million people worldwide. In 2017, deaths due to CKD accounted for 4.6% of mortality globally. Prevalence of CKD is increasing worldwide, with increasing diabetes and hypertension in aging populations. Our objective was to determine prevalence of CKD in an urban, adult cohort, since such data is scarce in Sri Lanka. Methods The study population was selected by stratified random sampling from Ragama MOH area initially in 2007 (aged 35-64 years) and re-assessed in 2014. On both occasions, participants were assessed by structured interview, anthropometric measurements and biochemical tests. CKD was assessed in 2014. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI formula. CKD was defined as eGFR<60ml/min/1.72m2, using KDIGO/KDOQI classification. The cohort was further followed up in 2017 when all-cause and cardiovascular (CV) mortality and CV morbidity were also assessed. Results Of 2985 individuals recruited in 2007, 2148(71.6%) attended follow-up in 2014. 2032/2148 (94.6%) had CKD data [57.0% women, mean age 52.3(SD 7.7) years]. Age adjusted prevalence of CKD was 3.03(1.98–4.11) per 100 population in 2014; 41/61(67.2%) were in CKD Stage-3A, 14/61(23%) in Stage-3B, 6/61(9.8%) in Stage-4 and none in end-stage. Independent predictors of CKD in 2014 were older age (p<0.001), male gender (P<0.05) and presence of diabetes (p<0.001) and hypertension (p<0,001) in 2007. CKD was not associated with all-cause mortality, CV mortality or morbidity (p>0.05) in 2017.Conclusion Diabetes and hypertension were associated with CKD. Most with CKD were in Stage 3, where early recognition and better control of co-morbidities retard progression of CKD. en_US
dc.language.iso en en_US
dc.publisher Sri Lanka Medical Association en_US
dc.subject kidney disease en_US
dc.title Prevalence, predictors and outcome of chronic kidney disease in a cohort of aging urban, adult Sri Lankans en_US
dc.type Conference Abstract en


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