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Sirtuins as potential therapeutic targets for mitigating neuroinflammation associated with Alzheimer's disease

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dc.contributor.author Fernando, K.K.M.
dc.contributor.author Wijayasinghe, Y.S.
dc.date.accessioned 2021-11-05T06:47:44Z
dc.date.available 2021-11-05T06:47:44Z
dc.date.issued 2021
dc.identifier.citation Frontiers in Cellular Neuroscience.2021;15:746631 en_US
dc.identifier.issn 1662-5102 (Electronic)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/23844
dc.description Not indexed for MEDLINE. In PUBMED en_US
dc.description.abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder, which is associated with memory deficit and global cognitive decline. Age is the greatest risk factor for AD and, in recent years, it is becoming increasingly appreciated that aging-related neuroinflammation plays a key role in the pathogenesis of AD. The presence of β-amyloid plaques and neurofibrillary tangles are the primary pathological hallmarks of AD; defects which can then activate a cascade of molecular inflammatory pathways in glial cells. Microglia, the resident macrophages in the central nervous system (CNS), are the major triggers of inflammation; a response which is typically intended to prevent further damage to the CNS. However, persistent microglial activation (i.e., neuroinflammation) is toxic to both neurons and glia, which then leads to neurodegeneration. Growing evidence supports a central role for sirtuins in the regulation of neuroinflammation. Sirtuins are NAD+-dependent protein deacetylases that modulate a number of cellular processes associated with inflammation. This review examines the latest findings regarding AD-associated neuroinflammation, mainly focusing on the connections among the microglial molecular pathways of inflammation. Furthermore, we highlight the biology of sirtuins, and their role in neuroinflammation. Suppression of microglial activity through modulation of the sirtuin activity has now become a key area of research, where progress in therapeutic interventions may slow the progression of Alzheimer's disease. en_US
dc.language.iso en en_US
dc.publisher Frontiers Research Foundation,Lausanne, Switzerland en_US
dc.subject Alzheimer’s Disease- en_US
dc.title Sirtuins as potential therapeutic targets for mitigating neuroinflammation associated with Alzheimer's disease en_US
dc.type Article en_US


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