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Cadmium a metalloestrogen: are we convinced?

Show simple item record Silva, N. en_US Peiris-John, R. en_US Wickremasinghe, R. en_US Senanayake, H. en_US Sathiakumar, N. en_US 2014-10-29T09:39:58Z 2014-10-29T09:39:58Z 2012 en_US
dc.identifier.citation Journal of Applied Toxicology; 32(5): pp.318-32 en_US
dc.identifier.issn 0260-437X (Print) en_US
dc.identifier.issn 1099-1263 (Electronic) en_US
dc.description.abstract Metalloestrogens are inorganic metal ions that bind to and activate oestrogen receptors. They are implicated in the aetiology of oestrogen-dependent diseases such as cancers of the breast and endometrium as well as endometriosis. Cadmium is one of the most studied metalloestrogens. In this review, scientific evidence for the oestrogenic effects of cadmium is critically evaluated to determine if there is sufficient evidence to support cadmium as an aetiological factor of oestrogen-dependent disease in humans. Results of the review indicated that, although the in vitro and in vivo evidence of the oestrogenic properties of cadmium was persuasive, evidence from population-based human studies remains conflicting. Considerable knowledge gaps exist on the potential oestrogenic effect of cadmium in humans. Research that focuses on bridging these knowledge gaps would be useful in preventing and managing oestrogen-dependent disease in humans en_US
dc.publisher Wiley en_US
dc.subject METALS, HEAVY en_US
dc.subject Cadmium en_US
dc.subject Cadmium-toxicity en_US
dc.subject Estrogens-toxicity en_US
dc.subject Metals, Heavy-toxicity en_US
dc.subject Breast Neoplasms en_US
dc.subject Breast Neoplasms-metabolism en_US
dc.title Cadmium a metalloestrogen: are we convinced? en_US
dc.type Review en_US
dc.identifier.department Public Health en_US
dc.creator.corporateauthor Genetic Toxicology Association en_US
dc.description.note Indexed in MEDLINE en_US

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