Digital Repository

Zinc supplementation in chronic kidney disease of unknown aetiology in Sri Lanka: a pilot study. (ZisCKDu-P)

Show simple item record

dc.contributor.author Abeysundara, P.K.
dc.contributor.author Nishad, N.
dc.contributor.author de Silva, S.T.
dc.contributor.author Dassanayake, R.T.
dc.contributor.author Galabada, D.P.
dc.contributor.author Jayawardane, U.G.W.
dc.contributor.author Premawardana, N.P.
dc.contributor.author Kumara, G.M.S.S.
dc.contributor.author Dilani, P.M.
dc.contributor.author Herath, H.M.T.D.
dc.contributor.author Wijesinghe, P.S.
dc.date.accessioned 2021-02-19T07:41:06Z
dc.date.available 2021-02-19T07:41:06Z
dc.date.issued 2020
dc.identifier.citation Journal of the Ceylon College of Physicians.2020; 51(2): 82–90. en_US
dc.identifier.issn 2448-9514
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/22016
dc.description Not indexed in MEDLINE en_US
dc.description.abstract INTRODUCTION: It was hypothesized that the antioxidant properties of zinc retard the progression of chronic kidney disease of unknown etiology in the North Central Province of Sri Lanka. METHODS: The pilot study was a randomized, placebo-controlled, single blinded, parallel group, single-center clinical trial with two arms (Z and P) and a 1:1 allocation ratio. Participants in group Z (n=20) received 60 mg of elemental zinc daily, in the form of zinc sulfate, and group P (n=21) received a starch tablet per day. Clinical, hematological parameters and kidney function were measured at the baseline and following three months of the intervention. RESULTS: A total of 86 CKDu patients were screened; only 35 males and 6 females were selected. Mean age and estimated glomerular filtration rate of the study population were 51.2±6.2 years and 38.9±8.8 mL/min/1.73 m2 respectively. At the end of three months there was non-significant increase in urine protein creatinine ratio (Z arm: 65±54 vs. 82± 86 mg/mmol; P=0.46, P arm: 72.4±113 vs. 120± 209 mg/mmol; P=0.36) and non-significant decline in estimated glomerular filtration rate (Z arm: 40.9±10.4 vs. 39.7±9.2 mL/min/1.73 m2; P=0.31, P arm: 37.1±6.8 vs. 36.4±10 mL/min/1.73m2; P=0.31) in both groups. Body mass index was significantly reduced (23±4 vs. 22.7± 3.9 kg/m2; P=0.01) and diastolic blood pressure was significantly increased (78±6 vs. 86±10 mmHg; P=0.001) in the placebo arm. Haemoglobin levelshowed a decline in the study group; 0.33±1 g/dl, while there was an increase in the placebo group, 0.34±0.7 g/dl, (P=0.02). There were no major side effects. CONCLUSIONS: The change of urine protein: creatinine ratio and estimated glomerular filtration rate did not show a significant difference between the two groups. A future trial should test effectiveness of same dose of zinc for a similar duration of time in a larger sample. Extended follow-up of the study subjects for one year after the intervention would be useful to assess the long-term effects of zinc on kidney function and side effects. en_US
dc.language.iso en_US en_US
dc.publisher Ceylon College of Physicians en_US
dc.subject chronic kidney disease en_US
dc.title Zinc supplementation in chronic kidney disease of unknown aetiology in Sri Lanka: a pilot study. (ZisCKDu-P) en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search Digital Repository


Browse

My Account