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The Impact of Empirical Hydrocortisone Therapy on Clinical Outcomes in Dengue Fever: A Retrospective Chart Review

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dc.contributor.author De Mel, S.
dc.contributor.author Thilakawardana, B. U.
dc.contributor.author De Mel, P.
dc.contributor.author de Silva, A. P.
dc.contributor.author de Mel, C.
dc.contributor.author Chandrasena, L.
dc.contributor.author Seneviratne, S. L.
dc.contributor.author Abeysuriya, V.
dc.date.accessioned 2020-06-26T05:39:15Z
dc.date.available 2020-06-26T05:39:15Z
dc.date.issued 2020
dc.identifier.citation Transactions of the Royal Society of Tropical Medicine and Hygiene. 2020;traa049. doi: 10.1093/trstmh/traa049. Online ahead of print. en_US
dc.identifier.issn 0035-9203 (Print)
dc.identifier.issn 1878-3503 (Electronic)
dc.identifier.issn 0035-9203 (Linking)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/21132
dc.description Indexed in MEDLINE en_US
dc.description.abstract BACKGROUND: The role of steroids in dengue infection (DI) remains uncertain. METHODS: A retrospective chart review was conducted on patients ≥18 y of age diagnosed with DI based on positivity for dengue non-structural antigen 1 or immunoglobulin M between October 2017 and November 2018. RESULTS: Hydrocortisone was administered to 106 of 406 patients. DI with warning signs occurred in nine patients (9.5%) in the steroid cohort and eight patients (2.5%) in the non-steroid group. The incidence of severe DI, bleeding and admission duration were similar between the groups. CONCLUSIONS: Our study shows no significant benefit of empirical steroids in DI. KEYWORDS: clinical outcomes; corticosteroids; dengue. en_US
dc.language.iso en_US en_US
dc.publisher Transactions of the Royal Society of Tropical Medicine and Hygiene. en_US
dc.subject empirical hydrocortisone en_US
dc.title The Impact of Empirical Hydrocortisone Therapy on Clinical Outcomes in Dengue Fever: A Retrospective Chart Review en_US
dc.type Article en_US


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