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Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
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Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Show simple item record Bentley, A.R. Chasman, D. I. Schwander, K. Ntalla, I. Kraja, A.T. Winkler, T.W. Brown, M. R. Sung, Y. J. Lim, E. Huffman, J.E. Vojinovic, D. Sim, X. Cheng, C.Y. Lu, Y. Liu, J. Guo, X. Deng, X. Musani, S.K. Li, C. Feitosa, M.F. Richard, M.A. Noordam, R. Baker, J. Chen, G. Aschard, H. Bartz, T.M. Ding, J. Dorajoo, R. Manning, A.K. Rankinen, T. Smith, A. V. Tajuddin, S.M. Zhao, W. Graff, M. Alver, M. Boissel, M. Chai, J. F. Chen, X. Divers, J. Evangelou, E. Gao, C. Goel, A. Hagemeijer, Y. Harris, S. E. Hartwig, F. P. He, M. Horimoto, A.R.V. R. Hsu, F.C. Hung, Y. J. Jackson, A. U. Kasturiratne, A. Komulainen, P. Kühnel, B. Leander, K. Lin, K. H. Luan, J. Lyytikäinen, L.P. Matoba, N. Nolte, I. M. Pietzner, M. Prins, B. Riaz, M. Robino, A. Said, M. A. Schupf, N. Scott, R. A. Sofer, T. Stancáková, A. Takeuchi, F. Tayo, B. O. van der Most, P. J. Varga, T. V. Wang, T. D. Wang, Y. Ware, E. B. Wen, W. Xiang, Y. B. Yanek, L. R. Zhang, W. Zhao, J. H. Adeyemo, A. Afaq, S. Amin, N. Amini, M. Arking, D.E. Arzumanyan, Z. Aung, T. Ballantyne, C. Barr, R. G. Bielak, L. F. Boerwinkle, E. Bottinger, E.P. Broeckel, U. Chen, Y. I. Charumathi, S. Canouil, M. Campbell, A. Cade, B. E. Brown, M. Christensen, K. de Las Fuentes, L. Connell, J. M. Concas, M. P. COGENT-Kidney Consortium de Silva, H.J. de Vries, P. S. Doumatey, A. Duan, Q. Eaton, C. B. Eppinga, R.N. Faul, J. D. Floyd, J.S. Gigante, B. Gharib, S. A. Forouhi, N.G. Ghanbari, M. Gao, H. Gandin, I. Friedlander, Y. Forrester, T. Hixson, J. E. Hirata, M. Justice, A. E. Jonas, J. B. Johnson, C. Joehanes, R. Jia, Y. EPIC-InterAct Consortium Ikram, M.A. Katsuya, T. Khor, C.C. Kilpeläinen, T.O. Koh, W. P. Kolcic, I. Kooperberg, C. Krieger, J.E. Kritchevsky, S.B. Kubo, M. Kuusisto, J. Lakka, T. A. Langefeld, C.D. Langenberg, C. Launer, L. J. Lehne, B. Lewis, C. E. Li, Y. Liang, J. Lin, S. Liu, C.T. Liu, J. Liu, K. Loh, M. Lohman, K.K. Louie, T. Luzzi, A. Mägi, R. Mahajan, A. Manichaikul, A.W. McKenzie, C.A. Meitinger, T. Metspalu, A. Milaneschi, Y. Milani, L. Mohlke, K. L. Momozawa, Y. Morris, A. P. Murray, A. D. Nalls, M. A. Nauck, M. Nelson, C. P. North, K. E. O'Connell, J.R. Palmer, N.D. Papanicolau, G.J. Pedersen, N. L. Peters, A. Peyser, P. A. Polasek, O. Poulter, N. Raitakari, O.T. Reiner, A. P. Renström, F. Rice, T.K. Rich, S.S. Robinson, J.G. Rose, L. M. Rosendaal, F. R. Rudan, I. Schmidt, C.O. Schreiner, P. J. Scott, W.R. Sever, P. Shi, Y. Sidney, S. Sims, M. Smith, J. A. Snieder, H. Starr, J. M. Strauch, K. Stringham, H. M. Tan, N. Y. Q. Tang, H. Taylor, K. D. Teo, Y. Y. Tham, Y. C. Tiemeier, H. Turner, S. T. Uitterlinden, A. G. Understanding Society Scientific Group van Heemst, D. Waldenberger, M. Wang, H. Wang, L. Wang, L. Wei, W. B. Williams, C. A. Wilson, G. Sr. Wojczynski, M. K. Yao, J. Young, K. Yu, C. Yuan, J. M. Zhou, J. Zonderman, A. B. Becker, D. M. Boehnke, M. Bowden, D. W. Chambers, J. C. Cooper, R. S. de Faire, U. Deary, I. J. Elliott, P. Esko, T. Farrall, M. Franks, P. W. Freedman, B. I. Froguel, P. Gasparini, P. Gieger, C. Horta, B. L. Juang, J. J. Kamatani, Y. Kammerer, C. M. Kato, N. Kooner, J. S. Laakso, M. Laurie, C. C. Lee, I. T. Lehtimäki, T. Lifelines Cohort Magnusson, P. K. E. Oldehinkel, A. J. Penninx, B. W. J. H. Pereira, A. C. Rauramaa, R. Redline, S. Samani, N. J. Scott, J. Shu, X. O. van der Harst, P. Wagenknecht, L. E. Wang, J. S. Wang, Y. X. Wareham, N. J. Watkins, H. Weir, D. R. Wickremasinghe, A.R. Wu, T. Zeggini, E. Zheng, W. Bouchard, C. Evans, M. K. Gudnason, V. Kardia, S. L. R. Liu, Y. Psaty, B. M. Ridker, P. M. van Dam, R. M. Mook-Kanamori, D. O. Fornage, M. Province, M. A. Kelly, T. N. Fox, E. R. Hayward, C. van Duijn, C. M. Tai, E. S. Wong, T. Y. Loos, R. J. F. Franceschini, N. Rotter, J. I. Zhu, X. Bierut, L. J. Gauderman, W. J. Rice, K. Munroe, P. B. Morrison, A. C. Rao, D. C. Cupples, L. A. Rotimi, C. N. 2019-06-03T09:19:26Z 2019-06-03T09:19:26Z 2019
dc.identifier.citation Nature Genetics.2019;51(4):636-648 en_US
dc.identifier.issn 1061-4036 (Print)
dc.identifier.issn 1546-1718 (Electronic)
dc.description indexed in MEDLINE en_US
dc.description.abstract The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. en_US
dc.language.iso en en_US
dc.publisher Nature Publishing Group en_US
dc.subject Smoking en_US
dc.title Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. en_US
dc.type Article en_US

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