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Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

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dc.contributor.author Bentley, A. R.
dc.contributor.author Chasman, D. I.
dc.contributor.author Schwander, K.
dc.contributor.author Ntalla, I.
dc.contributor.author Kraja, A. T.
dc.contributor.author Winkler, T. W.
dc.contributor.author Brown, M. R.
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dc.contributor.author Lim, E.
dc.contributor.author Huffman, J. E.
dc.contributor.author Vojinovic, D.
dc.contributor.author Sim, X.
dc.contributor.author Cheng, C. Y.
dc.contributor.author Lu, Y.
dc.contributor.author Liu, J.
dc.contributor.author Guo, X.
dc.contributor.author Deng, X.
dc.contributor.author Musani, S. K.
dc.contributor.author Li, C.
dc.contributor.author Feitosa, M. F.
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dc.contributor.author Noordam, R.
dc.contributor.author Baker, J.
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dc.contributor.author Dorajoo, R.
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dc.contributor.author Rankinen, T.
dc.contributor.author Smith, A. V.
dc.contributor.author Tajuddin, S. M.
dc.contributor.author Zhao, W.
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dc.contributor.author de Las Fuentes, L.
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dc.contributor.author COGENT-Kidney Consortium
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dc.contributor.author EPIC-InterAct Consortium
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dc.contributor.author Reiner, A. P.
dc.contributor.author Renström, F.
dc.contributor.author Rice, T. K.
dc.contributor.author Rich, S. S.
dc.contributor.author Robinson, J. G.
dc.contributor.author Rose, L. M.
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dc.contributor.author Schreiner, P. J.
dc.contributor.author Scott, W. R.
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dc.contributor.author Sidney, S.
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dc.contributor.author Tiemeier, H.
dc.contributor.author Turner, S. T.
dc.contributor.author Uitterlinden, A. G.
dc.contributor.author Understanding Society Scientific Group
dc.contributor.author van Heemst, D.
dc.contributor.author Waldenberger, M.
dc.contributor.author Wang, H.
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dc.contributor.author Lifelines Cohort
dc.contributor.author Magnusson, P. K. E.
dc.contributor.author Oldehinkel, A. J.
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dc.contributor.author Shu, X. O.
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dc.contributor.author Wang, J. S.
dc.contributor.author Wang, Y. X.
dc.contributor.author Wareham, N. J.
dc.contributor.author Watkins, H.
dc.contributor.author Weir, D. R.
dc.contributor.author Wickremasinghe, A. R.
dc.contributor.author Wu, T.
dc.contributor.author Zeggini, E.
dc.contributor.author Zheng, W.
dc.contributor.author Bouchard, C.
dc.contributor.author Evans, M. K.
dc.contributor.author Gudnason, V.
dc.contributor.author Kardia, S. L. R.
dc.contributor.author Liu, Y.
dc.contributor.author Psaty, B. M.
dc.contributor.author Ridker, P. M.
dc.contributor.author van Dam, R. M.
dc.contributor.author Mook-Kanamori, D. O.
dc.contributor.author Fornage, M.
dc.contributor.author Province, M. A.
dc.contributor.author Kelly, T. N.
dc.contributor.author Fox, E. R.
dc.contributor.author Hayward, C.
dc.contributor.author van Duijn, C. M.
dc.contributor.author Tai, E. S.
dc.contributor.author Wong, T. Y.
dc.contributor.author Loos, R. J. F.
dc.contributor.author Franceschini, N.
dc.contributor.author Rotter, J. I.
dc.contributor.author Zhu, X.
dc.contributor.author Bierut, L. J.
dc.contributor.author Gauderman, W. J.
dc.contributor.author Rice, K.
dc.contributor.author Munroe, P. B.
dc.contributor.author Morrison, A. C.
dc.contributor.author Rao, D. C.
dc.contributor.author Cupples, L. A.
dc.contributor.author Rotimi, C. N.
dc.date.accessioned 2019-06-03T09:19:26Z
dc.date.available 2019-06-03T09:19:26Z
dc.date.issued 2019
dc.identifier.citation Nature Genetics.2019;51(4):636-648 en_US
dc.identifier.issn 1061-4036 (Print)
dc.identifier.issn 1546-1718 (Electronic)
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/20296
dc.description indexed in MEDLINE en_US
dc.description.abstract The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. en_US
dc.language.iso en en_US
dc.publisher Nature Publishing Group en_US
dc.subject Smoking en_US
dc.title Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. en_US
dc.type Article en_US


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