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Pre-operative hypoalbunaemia is associated with poor overall survival in rectal cancer.

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dc.contributor.author Chandrasinghe, P.C.
dc.contributor.author Ediriweera, E.P.D.S.
dc.contributor.author Kumarage, S.K.
dc.contributor.author Deen, K.I.
dc.date.accessioned 2019-02-20T06:17:22Z
dc.date.available 2019-02-20T06:17:22Z
dc.date.issued 2012
dc.identifier.citation The Annual Sessions of the College of Surgeons of Sri Lanka.2012: 139 en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/19956
dc.description Free Papers Abstract (OP 2.32), 41st Annual Academic Sessions of the College of Surgeons of Sri Lanka jointly held with the royal college of surgeons of Edinburgh, 15th -18th August 2012 Colombo, Sri Lanka en_US
dc.description.abstract INTRODUCTION: Serum albumin is a marker of nutrition and inflammation. It has recently emerged as a predictor of outcome after surgery for rectal cancer. Our aim was to evaluate if pre-operative serum albumin would predict survival after resection for rectal cancer. METHOD: 226 Patients with rectal cancer of all stages undergoing resection with curative intent were studied. Kaplan-Meier curves analysed survival based on a pre-operative albumin level of <35g/L vs. >35g/L. We sought for significant associations of survival with age, sex, stage, tumour site, use of neoadjuvant chemoradiation, microscopic positive resection margins (R1 ), differentiation, angio, peri-neural, and lymphovascular invasion using individual variable analysis. Multifactorial analysis was performed using type III analysis with Weibull hazard model and Cox-proportional hazard model. Significance was assigned to a P value <0.05. RESULTS: Of 226 patients (median age- 59 years; range 19 - 88, Male - 54%), forty five (20%) had an albumin level < 35g/L and was associated with a poor overall survival (P=0.01). Mean survival in months for <35g/ s. >35g/L was 64.7 (SE - 9.3) vs. 95.8 (SE - 7.0). Individual variable anaysis revealed age, circumferential margin, stage,, perineural, lymphovascular and angio invasion to be also significant. With multifactorial analysis hypo-albunaemia (HR= 0.58, P=0.03), advanced stage (HR= 2.0, P < 0.01 ) and R1 circumferential margin (HR= 2.2, P < 0.01) remained significant. CONCLUSION: Preoperative hypoalbunaemia is an independent risk factor for poor overall survival in rectal cancer. Advanced tumour stage and R1 circumferential margin were the other associations with poor survival. en_US
dc.language.iso en en_US
dc.publisher The College of Surgeons of Sri Lanka en_US
dc.subject Hypoalbunaemia en_US
dc.title Pre-operative hypoalbunaemia is associated with poor overall survival in rectal cancer. en_US
dc.type Conference Abstract en_US


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