Basics in molecular evolution of colorectal cancer and their implications for the surgeon: is it a 'big-bang' or a 'survival of the toughest'?

dc.contributor.author	Chandrasinghe, P.C.	en
dc.date.accessioned	2019-01-09T04:53:44Z	en
dc.date.available	2019-01-09T04:53:44Z	en
dc.date.issued	2018	en_US
dc.identifier.citation	The Sri Lanka Journal of Surgery. 2018;36(2):18-21	en_US
dc.identifier.issn	1391-491X (Print)	en_US
dc.identifier.issn	2279-2201(Online)	en
dc.identifier.uri	http://repository.kln.ac.lk/handle/123456789/19390	en
dc.description.abstract	Multi disciplinary management of cancer has enabled a comprehensive involvement of clinicians in disease management. For the surgeon involved in colorectal cancer (CRC) management it is pertinent to possess a basic knowledge in tumour biology for effective participation. Several models exist to explain the intra tumour heterogeneity (ITH) seen in cancers; clonal expansion, big-bang theory and the cancer stem cell theory. All of these aim to describe the extreme variability seen within cell populations in solid tumours and their implications on clinical management. This review aims to provide the practising surgeon a basic knowledge of colorectal tumour biology and their implications in clinical phenomena.	en_US
dc.language.iso	en	en_US
dc.publisher	College of Surgeons of Sri Lanka	en_US
dc.subject	Colorectal cancer	en_US
dc.title	Basics in molecular evolution of colorectal cancer and their implications for the surgeon: is it a 'big-bang' or a 'survival of the toughest'?	en_US
dc.type	Article	en_US

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