dc.contributor.author | Ng, S.C. | en |
dc.contributor.author | Kaplan, G.G. | en |
dc.contributor.author | Tang, W. | en |
dc.contributor.author | Banerjee, R. | en_US |
dc.contributor.author | Adigopula, B. | en |
dc.contributor.author | Underwood, F.E. | en |
dc.contributor.author | Tanyingoh, D. | en |
dc.contributor.author | Wei, S.C. | en_US |
dc.contributor.author | Lin, W.C. | en_US |
dc.contributor.author | Lin, H.H. | en |
dc.contributor.author | Li, J. | en |
dc.contributor.author | Bell, S. | |
dc.contributor.author | Niewiadomski, O. | en_US |
dc.contributor.author | Kamm, M.A. | en_US |
dc.contributor.author | Zeng, Z. | en_US |
dc.contributor.author | Chen, M. | en |
dc.contributor.author | Hu, P. | en_US |
dc.contributor.author | Ong, D. | en_US |
dc.contributor.author | Ooi, C.J. | en_US |
dc.contributor.author | Ling, K. L. | en_US |
dc.contributor.author | Miao, Y. | en_US |
dc.contributor.author | Miao, J. | en_US |
dc.contributor.author | de Silva, H.J. | en_US |
dc.contributor.author | Niriella, M.A. | en_US |
dc.contributor.author | Aniwan, S. | en_US |
dc.contributor.author | Limsrivilai, J. | en_US |
dc.contributor.author | Pisespongsa, P. | en_US |
dc.contributor.author | Wu, K. | en_US |
dc.contributor.author | Yang, H. | en |
dc.contributor.author | Ng, K.K. | en |
dc.contributor.author | Yu, H. H. | en |
dc.contributor.author | Wang, Y. | en |
dc.contributor.author | Ouyang, Q. | en |
dc.contributor.author | Abdullah, M. | en |
dc.contributor.author | Simadibrata, M. | en |
dc.contributor.author | Gunawan, J. | en |
dc.contributor.author | Hilmi, I. | en |
dc.contributor.author | Goh, K. L. | en |
dc.contributor.author | Cao, Q. | en |
dc.contributor.author | Sheng, H. | en |
dc.contributor.author | Ong-Go, A. | en |
dc.contributor.author | Chong, V. H. | en |
dc.contributor.author | Ching, J. Y. L. | en |
dc.contributor.author | Wu, J. C. Y. | en |
dc.contributor.author | Chan, F.K.L. | en |
dc.contributor.author | Sung, J.J.Y. | en |
dc.date.accessioned | 2019-01-03T08:54:43Z | en |
dc.date.available | 2019-01-03T08:54:43Z | en |
dc.date.issued | 2019 | en |
dc.identifier.citation | The American Journal of Gastroenterology. 2019;114(1):107-115 | en_US |
dc.identifier.issn | 0002-9270 (Print) | en |
dc.identifier.issn | 1572-0241 (Electronic) | en |
dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/19293 | en |
dc.description | Indexed in MEDLINE | en_US |
dc.description.abstract | INTRODUCTION: Living in an urban environment may increase the risk of developing inflammatory bowel disease (IBD). It is unclear if this observation is seen globally. We conducted a population-based study to assess the relationship between urbanization and incidence of IBD in the Asia-Pacific region. METHODS: Newly diagnosed IBD cases between 2011 and 2013 from 13 countries or regions in Asia-Pacific were included. Incidence was calculated with 95% confidence interval (CI) and pooled using random-effects model. Meta-regression analysis was used to assess incidence rates and their association with population density, latitude, and longitude. RESULTS: We identified 1175 ulcerative colitis (UC), 656 Crohn's disease (CD), and 37 IBD undetermined (IBD-U). Mean annual IBD incidence per 100 000 was 1.50 (95% CI: 1.43-1.57). India (9.31; 95% CI: 8.38-10.31) and China (3.64; 95% CI, 2.97-4.42) had the highest IBD incidence in Asia. Incidence of overall IBD (incidence rate ratio [IRR]: 2.19; 95% CI: 1.01-4.76]) and CD (IRR: 3.28; 95% CI: 1.83-9.12) was higher across 19 areas of Asia with a higher population density. In China, incidence of IBD (IRR: 2.37; 95% CI: 1.10-5.16) and UC (IRR: 2.63; 95% CI: 1.2-5.8) was positively associated with gross domestic product. A south-to-north disease gradient (IRR: 0.94; 95% CI: 0.91-0.98) was observed for IBD incidence and a west-to-east gradient (IRR: 1.14; 95% CI: 1.05-1.24) was observed for CD incidence in China. This study received IRB approval. CONCLUSIONS: Regions in Asia with a high population density had a higher CD and UC incidence. Coastal areas within China had higher IBD incidence. With increasing urbanization and a shift from rural areas to cities, disease incidence may continue to climb in Asia. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wolters Kluwer Health | en_US |
dc.subject | Bowel Disease | en_US |
dc.title | Population density and risk of inflammatory bowel disease: a prospective population-based study in 13 countries or regions in Asia-Pacific. | en_US |
dc.type | Article | en_US |
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |