Digital Repository

Human-porcine reassortant rotavirus generated by multiple reassortment events in a Sri Lankan child with diarrhea

Show simple item record Yahiro, T. en Takaki, M. en Chandrasena, T.G.A.N. en Rajindrajith, S. en_US Isa, H. en Ahmed, K. en 2019-01-03T05:04:03Z en 2019-01-03T05:04:03Z en_US 2018 en_US
dc.identifier.citation Infection, Genetics and Evolution. 2018;65:170-186 en_US
dc.identifier.issn 1567-1348 (Print)
dc.identifier.issn 1567-7257 (Electronic)
dc.identifier.issn 1567-1348 (Linking)
dc.description Indexed In MEDLINE en_US
dc.description.abstract A human-porcine reassortant rotavirus, strain R1207, was identified from 74 group A rotaviruses detected in 197 (37.6%) stool samples collected from patients who attended a tertiary care hospital in Ragama, Sri Lanka. This is the first report of a human-porcine reassortant rotavirus in Sri Lanka. The patient was a 12-month-old boy who had been hospitalized with fever and acute diarrhea with a duration of 6 days. The family had pigs at home before the birth of this boy. However, the neighbors still practice pig farming. The genotype constellation of R1207 was G4-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1. This is based on the assignment of all the eleven gene segments a full genome-based genotyping system. R1207 showed a 4-2-3-2 genomic electrophoretic migration pattern, which is characteristic of group A rotaviruses. Our analyses revealed that five (NSP2, NSP4, VP1, VP2, and VP7) of the 11 genes were closely related to the respective genes of porcine strains. Although the remaining six genes (NSP1, NSP3, NSP5, VP3, VP4, and VP6) were related to human strains, with the exception of the gene sequence of NSP1, all of these human strains were human-porcine reassortants. With a genogroup 1 genetic backbone, this strain was possibly formed via multiple genetic reassortments. We do not know whether this strain is circulating in pigs, as no data are available on porcine rotaviruses in Sri Lanka. Surveillance should be strengthened to determine the epidemiology of this genotype of rotavirus in Sri Lanka and to assess whether the infection was limited or sustained by ongoing human-to-human transmission. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier Science en_US
dc.subject Reassortant Viruses-genetics en_US
dc.subject Rotavirus-genetics en
dc.subject Rotavirus Infections-drug therapy en
dc.subject Rotavirus Infections-virology en
dc.subject Viral Nonstructural Proteins-genetics en
dc.subject Viral Structural Proteins-genetics en
dc.subject Child en
dc.subject Sri Lanka en
dc.title Human-porcine reassortant rotavirus generated by multiple reassortment events in a Sri Lankan child with diarrhea en_US
dc.type Article en_US

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Digital Repository


My Account