| dc.contributor.author | Salm, P. | en_US |
| dc.contributor.author | Taylor, P. J. | en_US |
| dc.contributor.author | Roberts, D. | en_US |
| dc.contributor.author | de Silva, J. | en_US |
| dc.date.accessioned | 2014-10-29T09:27:23Z | |
| dc.date.available | 2014-10-29T09:27:23Z | |
| dc.date.issued | 2009 | en_US |
| dc.identifier.citation | Journal of Chromatography B. 2009; 877(5-6): pp.568-74 | |
| dc.identifier.issn | 1570-0232 (Print) | en_US |
| dc.identifier.issn | 1873-376X (Electronic) | en_US |
| dc.identifier.uri | http://repository.kln.ac.lk/handle/123456789/1909 | |
| dc.description | Indexed in mEDLINE | |
| dc.description.abstract | Simultaneous determination of the organophosphorus pesticides dimethoate, fenthion, diazinon and chlorpyrifos in human blood by HPLC–tandem mass spectrometry was developed and validated. The pesticides were extracted by a simple one-step protein precipitation procedure. Chromatography was performed on a Luna C18 (30 mm × 2.0 mm, 3 μm) column, using a step-gradient at a flow rate of 0.4 ml/min. The assay was linear from 0.5 to 100 ng/ml (r2 > 0.992, n = 24) for all pesticides. The inter- and intra-day accuracy and precision for the method was 96.6–106.1% and <10%, respectively. The lower limit of quantification was 0.5 ng/ml. In conclusion, the method described displays analytical performance characteristics that are suitable for the quantification of these pesticides in cases of acute poisoning. | |
| dc.publisher | Elsevier | en_US |
| dc.title | Liquid chromatography-tandem mass spectrometry method for the simultaneous quantitative determination of the organophosphorus pesticides dimethoate, fenthion, diazinon and chlorpyrifos in human blood | en_US |
| dc.type | Article | en_US |
| dc.identifier.department | Medicine | en_US |
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