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Molecular profiling of advanced breast cancer tumors is beneficial in assisting clinical treatment plans

Show simple item record Carter, P. Alifrangis, C. Cereser, B. Chandrasinghe, P. Del Bel Belluz, L. Moderau, N. Poyia, F. Schwatzberg, L.S. Tabassum, N. Wen, J. Krell, J. Stebbing, J. 2018-07-04T03:47:31Z 2018-07-04T03:47:31Z 2018
dc.identifier.citation Oncotarget.2018;9(25):17589-17596 en_US
dc.identifier.issn 1949-2553 (Electronic)
dc.identifier.issn 1949-2553 (Linking)
dc.description.abstract We used data obtained by Caris Life Sciences, to evaluate the benefits of tailoring treatments for a breast carcinoma cohort by using tumor molecular profiles to inform decisions. Data for 92 breast cancer patients from the commercial Caris Molecular Intelligence database was retrospectively divided into two groups, so that the first always followed treatment recommendations, whereas in the second group all patients received at least one drug after profiling that was predicted to lack benefit. The biomarker and drug associations were based on tests including fluorescent in situ hybridization and DNA sequencing, although immunohistochemistry was the main test used. Patients whose drugs matched those recommended according to their tumor profile had an average overall survival of 667 days, compared to 510 days for patients that did not (P=0.0316). In the matched treatment group, 26% of patients were deceased by the last time of monitoring, whereas this was 41% in the unmatched group (P=0.1257). We therefore confirm the ability of tumor molecular profiling to improve survival of breast cancer patients. Immunohistochemistry biomarkers for the androgen, estrogen and progesterone receptors were found to be prognostic for survival. en_US
dc.language.iso en_US en_US
dc.publisher Impact Journals en_US
dc.subject Brest cancer en_US
dc.title Molecular profiling of advanced breast cancer tumors is beneficial in assisting clinical treatment plans en_US
dc.type Article en_US

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