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Intratumoural lymphatics in benign and malignant soft tissue tumours

Show simple item record Mahendra, G. en_US Kliskey, K. en_US Williams, K. en_US Hollowood, K. en_US Jackson, D. en_US Athanasou, N.A. en_US 2014-10-29T09:26:57Z 2014-10-29T09:26:57Z 2008 en_US
dc.identifier.citation Virchows Archiv A. 2008; 453(5): pp.457-64 en_US
dc.identifier.issn 0945-6317 (Print) en_US
dc.identifier.issn 1432-2307 (Electronic) en_US
dc.description Indexed in MEDLINE
dc.description.abstract Soft tissue sarcomas do not generally metastasise via lymphatics, and the presence or absence of lymphatic vessels within sarcomas and benignsoft tissue tumours is not known. In this study, we determined whether lymphatic vessels were present in a wide range of benign and malignant softtissue lesions by examining intratumoural expression of the lymphatic endothelial cell markers, Lyve-1 and podoplanin. Intratumoural Lyve-1+/podoplanin+ lymphatics were not identified in sarcomas apart from all cases of epithelioid sarcoma (a tumour which is known to metastasise to lymph nodes) and a few cases of leiomyosarcoma, rhabdomyosarcoma and synovial sarcoma. Intratumoural lymphatics were also absent in mostbenign soft tissue tumours. Reparative and inflammatory soft tissue lesions contained lymphatics, as did all (pseudosarcomatous) proliferative myofibroblastic lesions including nodular, proliferative and ischaemic fasciitis, elastofibroma, nuchal fibroma and deep fibromatosis. Our results show that most soft tissue sarcomas do not contain intratumoural lymphatics, a finding which is consistent with the infrequent finding of sarcoma metastasis to lymph nodes. In contrast to fibrosarcoma and a number of other malignant spindle cell tumours, proliferative fibroblastic/myofibroblastic lesions of soft tissue contain intralesional lymphatic vessels.
dc.publisher Springer International en_US
dc.title Intratumoural lymphatics in benign and malignant soft tissue tumours en_US
dc.type Article en_US
dc.identifier.department Pathology en_US

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