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Metabolic syndrome and risk of endometrial carcinoma among asymptomatic, postmenopausal, urban Sri Lankan females: a community cohort follow-up study

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dc.contributor.author Dias, T. en_US
dc.contributor.author Niriella, M. en_US
dc.contributor.author de Silva, S. en_US
dc.contributor.author Motha, C. en_US
dc.contributor.author Palihawadana, T.S. en_US
dc.contributor.author Ediriweera, D. en_US
dc.contributor.author de Silva, J. en_US
dc.date.accessioned 2018-03-06T15:54:50Z en_US
dc.date.available 2018-03-06T15:54:50Z en_US
dc.date.issued 2017 en_US
dc.identifier.citation Ultrasound in Obstetrics & Gynecology. 2017; 50(Suppl 1): 393 en_US
dc.identifier.issn 0960-7692 (Print) en_US
dc.identifier.issn 1469-0705 (Electronic) en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/18609 en_US
dc.description Electronic Poster Abstract (EP29.06), 27th World Congress on Ultrasound in Obstetrics and Gynecology, September 16–19, 2017, Vienna, Austria en_US
dc.description.abstract OBJECTIVES: Metabolic syndrome (MetS) has been recognised as a risk factor for malignancies. The aim of this study was to evaluate the association of MetS and risk of endometrial carcinoma (EC), by measuring endometrial thickness (ET). METHODS: The Ragama Health Study (RHS) recruited 35-64-year-old female cohort by age-stratified random sampling in 2007 and re-evaluated them in 2014, using a structured interview, anthropometric measurements and biochemical tests. Liver ultrasound to detect fatty liver was performed in 2007. Pelvic ultrasound to detect ET was performed in 2014 among consenting participants. MetS was diagnosed on established International Diabetes Federation (IDF 2012) criteria. Increased ET was defined as >5mm. Simple logistic regression was used to screen variables and multiple logistic regression was used to obtain adjusted effects of risk factors for increased ET. RESULTS: 813/1636(49.7%) of the original female cohort attended follow-up; ET was measured in 567(69.7%). Median (IQR) age of females was 61 (56-66) years. 323 fulfilled criteria for MetS (prevalence 57.1%) in 2007. 57(10.1%) had increased ET in 2014. Increasing plasma triglycerides [OR=1.004 per mg/dl, 95%CI:1.001-1.007, p<0.05] and being hypertensive [OR=2.16, 95%CI:1.11–4.08, p<0.05] were associated with increased ET, while advancing age [OR=0.93 per year, 95%CI:0.89–0.98, p<0.01] and being diabetic [OR= 0.34, 95%CI:0.10–0.89, p<0.05] were protective. CONCLUSIONS: Hypertension and increased plasma triglyceride levels, in the pre-menopausal period, were risk factors for future asymptomatic increased ET. en_US
dc.language.iso en_US en_US
dc.publisher Wiley Publishing en_US
dc.subject Endometrial Neoplasms en_US
dc.subject Metabolic Syndrome en_US
dc.subject Risk Factors en_US
dc.subject Endometrium-diagnostic imaging en_US
dc.subject Postmenopause en_US
dc.subject Women en_US
dc.subject Aged en_US
dc.subject Cohort Studies en_US
dc.title Metabolic syndrome and risk of endometrial carcinoma among asymptomatic, postmenopausal, urban Sri Lankan females: a community cohort follow-up study en_US
dc.type Conference Abstract en_US


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    Papers presented at local and international conferences by the Staff of the Faculty of Medicine

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