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Factors associated with urinary tract infections caused by extended spectrum beta-lactamase (ESBL) producing organisms in Sri Lanka

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dc.contributor.author Fernando, S. en_US
dc.contributor.author Luke, N. en_US
dc.contributor.author Wickramasinghe, S. en_US
dc.contributor.author Sebastiampillai, B. en_US
dc.contributor.author Gunathilake, M. en_US
dc.contributor.author Miththinda, N. en_US
dc.contributor.author Silva, S. en_US
dc.contributor.author Premaratna, R. en_US
dc.date.accessioned 2017-11-08T07:11:11Z en_US
dc.date.available 2017-11-08T07:11:11Z en_US
dc.date.issued 2016 en_US
dc.identifier.citation International Journal of Infectious Diseases. 2016; 45(Supl 1): 146 en_US
dc.identifier.issn 1201-9212(Print) en_US
dc.identifier.issn 1878-3511(Electronic) en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/17960 en_US
dc.description Abstract of the Poster Presentation (41.161), 17th International Congress on Infectious Diseases(ICID), March 2-5, 2016, Hyderabad, India en_US
dc.description.abstract BACKGROUND: Urinary tract infections (UTI) caused by extendedspectrum beta-lactamase (ESBL)-producing organisms are a major burden in clinical practice. Hospitalization in the past 3 months, antibiotic treatment in the past 3 months, age over 60 years, diabetes mellitus, Klebsiella pneumoniae infection, previous use of second or third-generation cephalosporins, quinolones or penicillins are known associations and risk factors for ESBL-UTI. METHODS & MATERIALS: A descriptive study was conducted over a period of 6 months from January - July 2015 recruiting patients with UTI caused by ESBL producing organisms, who were admitted to the Professorial Medical unit, Colombo North Teaching Hospital, Ragama Sri Lanka in order to identify risk factors and associations. Data were obtained using a pre-tested interviewer administered questionnaire and from relevant medical records after obtaining informed written consent. RESULTS: 52 patients were recruited; males 30 (57.7%), mean (SD) age 64.1(.12.6)years. Of them, 46 (88.5%) had diabetes mellitus, 32 (61.5%) had hypertension and 10 (19.2%) had chronic liver disease as comorbidities.20 (38.5%) had ultrasonographic evidence of acute pyelonephritis. At presentation16 (30.8%)had biochemical and/or ultrasonographic evidence of chronic or acute on chronic kidney disease. History of constipation was observed in 18 (34.6%), hospitalization during the past 3 months was seen in 24(46.2%)and history of urinary catheterization in 16(30.8%). Features of obstructive uropathy such as hydronephrosis, hydroureter and prostatomegaly were seen in 4 (7.7%) patients each. Antibiotic treatment within the past 3 months was observed in 32(61.5%);penicillins in 18(34.6%), 3rd generation cephalosporins in 16(30.8%),quinolones in 14(26.9%) and 2nd generation cehalosporins in 12 (23.1%). 18 (34.6%) had received more than one antibiotic within the past 3 months. 8(15.4%)patients studied were on prophylactic antibiotics for recurrant UTIs. None of them had recent Klebsiella pneumonia. CONCLUSION: Similar to other studies,diabetes mellitus, recent antibiotic treatment, hospitalization and catheterization were observed in our patients with ESBL-UTI. The fact that only 53.8% patients had received antibiotics at community level and 38.5% patients had never received antibiotics prior to developing ESBLUTI suggest high prevalence of ESBL producing organisms at community level. en_US
dc.description.sponsorship International Society for Infectious Diseases en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject Urinary Tract Infections en_US
dc.subject Risk Factors en_US
dc.subject Surveys and Questionnaires en_US
dc.subject Urinary Tract Infections-microbiology en_US
dc.subject beta-Lactamases en_US
dc.title Factors associated with urinary tract infections caused by extended spectrum beta-lactamase (ESBL) producing organisms in Sri Lanka en_US
dc.type Conference Abstract en_US


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