dc.contributor.author |
Siriwardana, R.C. |
en_US |
dc.contributor.author |
Liyanage, C.A.H. |
en_US |
dc.contributor.author |
Gunetilleke, B. |
en_US |
dc.contributor.author |
Niriella, M.A. |
en_US |
dc.contributor.author |
de Silva, H.J. |
en_US |
dc.contributor.author |
Dassanayake, A.S. |
en_US |
dc.contributor.author |
Jayatunga, S.P. |
en_US |
dc.date.accessioned |
2017-11-01T07:25:50Z |
en_US |
dc.date.available |
2017-11-01T07:25:50Z |
en_US |
dc.date.issued |
2017 |
en_US |
dc.identifier.citation |
Gastrointestinal Tumors.2017;4(1-2):20-27 |
en_US |
dc.identifier.issn |
2296-3774 (Print) |
en_US |
dc.identifier.issn |
2296-3766 (Electronic) |
en_US |
dc.identifier.issn |
2296-3774 (Linking) |
en_US |
dc.identifier.uri |
http://repository.kln.ac.lk/handle/123456789/17941 |
en_US |
dc.description |
Indexed in PUBMED, Not in MEDLINE |
en_US |
dc.description.abstract |
BACKGROUND: Data on diffuse-type hepatocellular carcinoma (HCC) are rare. HCC in Sri Lanka is rising, and the majority is related to nonalcoholic fatty liver disease. This study was planned to compare nodular- and diffuse-type HCC in this cohort. METHODS: CT scans of 227 patients with HCC negative for infective hepatitis were analyzed and grouped as nodular and diffuse from July 2011 to July 2014. Diffuse-type cancer was defined as a tumor without convex/distinct margin, diffusely infiltrating the hepatic parenchyma. There were 45 (20%) cases. The baseline liver functions, etiology, treatment, and the outcome were compared with nodular-type cancers. Stage III diffuse cancers were matched with 2 stage III nodular cancers looking at the T stage and background liver. RESULTS: There was no difference in the age (63 vs. 62 years, p = 0.937) and gender. Diffuse cancers had a low BMI (24 vs. 22, p = 0.009), a higher alpha fetoprotein (AFP) level (p < 0.001), a higher incidence of major vascular invasion (14 vs. 80%, p < 0.001), and a history of significant alcohol consumption (39 vs. 67%, p = 0.001). The baseline liver functions were similar in diffuse and nodular cancers. A large proportion (27 vs.77%, p < 0.001) of diffuse cancers were not candidates for active treatment. Overall survival was poor in the diffuse type(4.7 vs. 25 months, p < 0.001). Diffuse-type stage III cancers had a poor survival compared to matched nodular cancers (2.5 vs. 15.8 months, p = 0.001). CONCLUSION: HCC without a background of infective hepatitis were common in our cohort. These tumors are associated with high AFP levels, major vascular invasion, and a poor prognosis. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.publisher |
Karger Medical and Scientific Publishers |
en_US |
dc.subject |
Carcinoma, Hepatocellular |
en_US |
dc.subject.mesh |
Carcinoma, Hepatocellular-diagnosis |
en_US |
dc.subject.mesh |
Carcinoma, Hepatocellular-pathology |
en_US |
dc.subject.mesh |
Neoplasm Staging |
en_US |
dc.subject.mesh |
Neoplasm Invasiveness |
en_US |
dc.subject.mesh |
Prognosis |
en_US |
dc.title |
Diffuse-Type Hepatoma: A grave prognostic marker |
en_US |
dc.type |
Article |
en_US |