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“Silent” white matter changes in brain MRI in patients with haemoglobinopathies and their clinical significance

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dc.contributor.author Premawardhena, A.P.
dc.contributor.author Ranawaka, U.R.
dc.contributor.author Hapangama, A.
dc.contributor.author Pathmeswaran, A.
dc.contributor.author Hettiarachchi, S.
dc.contributor.author Salvin, K.A.
dc.contributor.author Pilapitiya, T.
dc.contributor.author Sanjaya, G.
dc.contributor.author Oilvieri, N.F.
dc.contributor.author Weatherall, D.J.
dc.date.accessioned 2017-10-11T05:13:39Z
dc.date.available 2017-10-11T05:13:39Z
dc.date.issued 2016
dc.identifier.citation Sri Lanka Medical Association, 129th Anniversary International Medical Congress. 2016: 176 en_US
dc.identifier.issn 0009-0895
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/17812
dc.description Poster Presentation Abstract (PP 46), 129th Anniversary International Medical Congress, Sri Lanka Medical Association, 25-27 July 2016 Colombo, Sri Lanka en_US
dc.description.abstract INTRODUCTION AND OBJECTIVES: Increasing interest has been directed to the study of white matter changes and lacunar infarcts in patients with haemoglobinopathies which are thought to be clinically silent. Previous studies suggest an association with splenectomy and thrombocytosis. The objective was to assess the association of white matter changes in patients with haemoglobinopathies. METHOD: Older patients with haemoglobinopthies attending the Hemals Thalassaemia Unit were assessed by a specialist neurologist and simultaneously had MRI brain. Relevant clinical, biochemical and hematological data were collected. A non-thalassaemic control group (age and sex matched) too were assessed. RESULTS: There were 82 patients (25 Thalassaemia Major,24 Intermedia and 33 Haemoglobin E b thalassaemia) and 19 controls. Mean age of the study group was 32yrs. 21 patients (26%) had MRI changes (20%,29%,27% in the three groups respectively) (p=0.73). 10% of controls had MRI changes. 12 (60%) of the patients with MRI changes were asplenic whilst 53.2% without changes were asplenic (P=0.138). There was no difference in the two groups with platelet counts. (Mean platelet count 581 Vs. 452 (p= 0.709) 58% of patients and 53% of controls had headache as a symptom. Headache was commoner among those with MRI changes (85% vs 51.6%; p=0.008). CONCLUSIONS: The white matter changes in MRI occurred in all three sub groups of thalassaemic patients studied in high frequency. To our knowledge, this is the first report of the association of MRI changes with neurological symptoms in thalassaemic patients. The higher frequency of headache in those with MRI changes suggest that these changes may not be silent as previously believed. en_US
dc.language.iso en_US en_US
dc.publisher Sri Lanka Medical Association en_US
dc.subject haemoglobinopathies en_US
dc.title “Silent” white matter changes in brain MRI in patients with haemoglobinopathies and their clinical significance en_US
dc.type Article en_US


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