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Pathogenesis of murine gammaherpesvirus infection in mice deficient in CD4 and CD8 T cells

Show simple item record Ehtisham, S. Sunil-Chandra, N.P. Nash, A.A. 2017-09-14T13:56:56Z 2017-09-14T13:56:56Z 1993
dc.identifier.citation Journal of virology. 1993; 67(9): 5247-52. en_US
dc.identifier.issn 0022-538X (Print)
dc.identifier.issn 1098-5514 (Electronic)
dc.identifier.issn 0022-538X (Linking)
dc.description Indexed in MEDLINE en_US
dc.description.abstract Murine gammaherpesvirus is a natural pathogen of wild mice. The virus infects alveolar cells and spleen cells during the primary infection and establishes a latent/persistent infection in B lymphocytes. Little is known about the immunological response to gammaherpesviruses during a primary infection. To address this issue, we investigated the pathogenesis of murine herpesvirus 68 (MHV-68) infection in mice deficient in CD4 or CD8 T-cell populations. Infection of the lung and spleen were greatly exacerbated in CD8-deficient mice, reflected by elevated virus titers in the lung and an increase in the number of infected splenocytes located around germinal centers. This finding contrasts with clearance of virus from the lung and spleen by day 12 postinfection in CD4-depleted animals. These data clearly indicate a major role for CD8 T cells in recovery from an acute MHV-68 infection. Whereas CD4 T cells fail to influence the course of infection in the lung, they do contribute to lymphoproliferation seen in the spleen (splenomegaly) during the primary infection. The significance of these results are discussed in relation to the immune response to other herpesviruses, in particular Epstein-Barr virus, with which MHV-68 shares similar molecular and biological properties. en_US
dc.language.iso en_US en_US
dc.publisher American Society for Microbiology. en_US
dc.subject Herpesviridae-isolation & purification en_US
dc.subject Herpesviridae-pathogenicity en_US
dc.subject Herpesviridae Infections-immunology en_US
dc.subject Herpesviridae Infections-microbiology en_US
dc.subject Herpesviridae Infections-pathology en_US
dc.subject T-Lymphocyte Subsets-immunology en_US
dc.subject Antigens, CD4 en_US
dc.subject Antigens, CD8 en_US
dc.subject Antigens, Viral en_US
dc.subject Gammaherpesvirinae en_US
dc.subject Gammaherpesvirinae-immunology en_US
dc.title Pathogenesis of murine gammaherpesvirus infection in mice deficient in CD4 and CD8 T cells en_US
dc.type Article en_US

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