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Clinical predictors of poor disease outcome for inflammatory bowel disease in Sri Lanka

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dc.contributor.author Niriella, M.A.
dc.contributor.author Kodisinghe, S.K.
dc.contributor.author Dassanayake, S.U.B.
dc.contributor.author Rajapakshe, N.
dc.contributor.author Nanayakkara, S.D.
dc.contributor.author Luke, H.P.D.P.
dc.contributor.author Silva, K.T.M.
dc.contributor.author de Silva, A.P.
dc.contributor.author Navarathne, N.M.M.
dc.contributor.author de Silva, H.J.
dc.date.accessioned 2017-09-07T07:22:04Z
dc.date.available 2017-09-07T07:22:04Z
dc.date.issued 2016
dc.identifier.citation Sri Lanka Medical Association, 129th Anniversary International Medical Congress. 2016: 105 en_US
dc.identifier.issn 0009-0895
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/17330
dc.description Oral Presentation Abstract (OP 06), 129th Anniversary International Medical Congress, Sri Lanka Medical Association, 25-27 July 2016 Colombo, Sri Lanka en_US
dc.description.abstract INTRODUCTION: There is limited data on clinical predictors of poor outcomes of inflammatory bowel disease from Sri Lanka. OBJECTIVES: To study clinical predictors of poor outcomes of inflammatory bowel disease among patients attending National Hospital of Sri Lanka and Colombo North Teaching Hospital. METHOD: Patients with ulcerative colitis (UC) and crohn disease(CD) of at least one year duration were included from Colombo North Teaching Hospital and National Hospital of Sri Lanka. Predictors of complicated disease (CompD) (structuring/penetrating-CD, extensive/pancolitis-UC), treatment refractoriness (TR) (frequently relapsing, steroid dependent, steroid refractory, need for biologics) and disease complications (DC) (perforation, bleeding, colectomy, malignancy) were assessed. Gender, age, duration at diagnosis, extra-intestinal manifestations (EIM), cigarette smoking and family history were assessed as independent risk factors using binary logistic regression. RESULTS: 287 patients were included [UC-208 (72.5%%), 100 (48.1%) males, median follow up (IQR) 74.5 (35.0–127.5) months; CD 79(27.5%), 37(46.8%) males, median follow up (IQR) 50.0 (29.0-84.0) months]. CompD was observed among 65(31.25%) UC and 20(25.31%) CD patients; family history (OR 4.103, adjusted p=0.029) was predictive of CompD in UC. TR was observed among 13(6.31%) UC and 9(11.39%) CD patients; non-smoking was predictive of TR in UC (OR=0.000, adjusted p=0.027). DC was seen in 8(3.86%) of UC and 11(13.92%) of CD. Family history (OR=16.457, adjusted p=0.001), EIM of skin (OR=14.071, adjusted p=0.039) and joints (OR=8.940, adjusted p=0.002) were predictive of DC in UC; eye EIM (OR=4.286, adjusted p=0.047) was predictive of DC in CD. CONCLUSIONS: CompD was not uncommon in UC and CD. TR and DC were uncommon. Family history, being a non-smoker, EIM of skin and joints independently predicted worse outcomes in UC, while EIM of eyes predicted a poor outcome in CD. en_US
dc.language.iso en_US en_US
dc.publisher Sri Lanka Medical Association en_US
dc.subject inflammatory bowel disease en_US
dc.title Clinical predictors of poor disease outcome for inflammatory bowel disease in Sri Lanka en_US
dc.type Article en_US


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