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The prevalence of cirrhosis in adults with evidence of immunity against Hepatitis A

Show simple item record Kobbegala, K.G.V.J. Karalliyadda, H.N. Ranawaka, C. Niriella, M. de Silva, A.P. Dassanayake, A.S. de Silva, H.J. 2017-09-07T05:26:26Z 2017-09-07T05:26:26Z 2016
dc.identifier.citation Sri Lanka Medical Association, 129th Anniversary International Medical Congress. 2016: 102 en_US
dc.identifier.issn 0009-0895
dc.description Oral Presentation Abstract (OP 01), 129th Anniversary International Medical Congress, Sri Lanka Medical Association, 25-27 July 2016 Colombo, Sri Lanka en_US
dc.description.abstract INTRODUCTION: Hepatitis A is a common and often asymptomatic infection in childhood in the developing world. With improving living standards in some developing countries, its incidence in childhood has decreased leading to a significant proportion of non-immune adults. The infection is a potentially serious illness in adults and can even be fatal in patients with cirrhosis. Vaccination against Hepatitis A is therefore recommended for non-immune cirrhotic. OBJECTIVES: To assess the prevalence of cirrhosis in adults with evidence of immunity against hepatitis A. METHOD: As part of their routine investigations, Hepatitis A Ig G antibodies (anti-HAV IgG) were checked using an ELISA technique in 108 cirrhotic patients presenting to a tertiary referral centre for the first time from 2011 to 2014. Patients’ demographic data were collected and the possible aetiology of cirrhosis investigated. RESULTS: The median age at presentation was 55 years (range 28-78) and the Male: Female ratio was 5:1. Most (62.5%) patients had cryptogenic cirrhosis and 27.7% patients had alcoholic cirrhosis. 48/110 patients (44.4%) were positive and 60 (56.6%) were negative for anti-HAV IgG. None of the patients had received vaccination against hepatitis A. CONCLUSIONS: Most of our patients presenting with cirrhosis did not have evidence of immunity against hepatitis A. In our setting, cirrhotic patients should be investigated for evidence of past infection with Hepatitis A, and vaccination offered to those found to be non-immune. en_US
dc.language.iso en_US en_US
dc.publisher Sri Lanka Medical Association en_US
dc.subject Hepatitis A en_US
dc.title The prevalence of cirrhosis in adults with evidence of immunity against Hepatitis A en_US
dc.type Article en_US

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