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Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo

Show simple item record Sunil-Chandra, N.P. Efstathiou, S. Nash, A.A. 2017-08-21T04:06:22Z 2017-08-21T04:06:22Z 1992
dc.identifier.citation Journal of General Virology. 1992; 73(12): 3275-3279. en_US
dc.identifier.issn 0022-1317 (Print)
dc.identifier.issn 1465-2099 (Electronic)
dc.identifier.issn 0022-1317 (Linking)
dc.identifier.uri en
dc.description Indexed in MEDLINE
dc.description.abstract Murine gammaherpesvirus 68 (MHV-68) is able to persist in spleen cells of infected mice. To determine the cell type harbouring persistent virus, spleen cells from infected animals were separated into immunoglobulin (Ig)-positive (B cell-enriched), Ig-negative (T cellenriched) and plastic-adherent (macrophage-enriched) fractions. These cells were co-cultivated with permissive BHK-21 cells in an infectious centre assay. The consistent recovery and enrichment of infectious centres in the Ig-positive fraction clearly demonstrates that B cells are a major site of virus persistence/latency. This observation indicates that MHV-68 is biologically similar to Epstein-Barr virus and other members of the B cell lymphotropic gammaherpesvirus 1 subgroup. en_US
dc.language.iso en en_US
dc.publisher Microbiology Society en_US
dc.subject B-Lymphocytes-microbiology en_US
dc.subject Herpesviridae-growth & development en_US
dc.subject Herpesviridae-pathogenicity en_US
dc.subject.mesh Gammaherpesvirinae
dc.subject.mesh Gammaherpesvirinae-genetics
dc.title Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo en_US
dc.type Article en_US

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