Digital Repository

In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani

Show simple item record Manamperi, N.H. Oghumu, S. Pathirana, N. de Silva, V.C. Abeyewickreme, W. Satoskar, A.R. Karunaweera, N.D. 2017-02-01T06:27:15Z 2017-02-01T06:27:15Z 2017
dc.identifier.citation Parasite Immunology. 2017; 39(3): e12413 en_US
dc.identifier.issn 0141-9838 (Print)
dc.identifier.issn 1365-3024 (Electronic)
dc.identifier.issn 0141-9838 (Linking)
dc.description Indexed in MEDLINE en_US
dc.description.abstract INTRODUCTION: Cutaneous leishmaniasis in Sri Lanka is a newly established parasitic disease caused by the usually visceralizing Leishmania donovani. Skin lesions manifest as non-itchy, non-tender papules, nodules or ulcers. In situ cytokine expression provides clues for immunopathogenesis of this localized form of disease. METHODS: Skin biopsies from 58 patients were analyzed for histological appearance and in situ cytokine expression of T- helper 1 (Th1) and T- helper 2 (Th2) cytokines, namely interferon (IFN)-γ, interleukin (IL)-12A, tumor necrosis factor (TNF)-α, IL-4 and IL-10 by real-time RT- PCR. RESULTS: Significant up regulation of the Th1 cytokine IFN-γ and down regulation of the Th2 cytokine IL-4 was seen in patients compared to healthy controls. Significantly elevated tissue expression of IFN-γ and TNF-α was seen in lesions that presented later than 6 months from the time of onset, while IL-4 expression was more prominent in lesions that responded poorly to antimony therapy. CONCLUSION: A prominent Th1 response appears to support resolving of lesions, whereas a Th2 biased milieu tends to favor poor responsiveness to antimony and delayed lesion healing in L. donovani infections in Sri Lanka. This article is protected by copyright. All rights reserved. en_US
dc.language.iso en_US en_US
dc.publisher Oxford, Wiley en_US
dc.subject Leishmaniasis en_US
dc.subject Leishmaniasis, Cutaneous en
dc.subject Leishmaniasis, Cutaneous - immunology en
dc.subject Leishmania donovani en
dc.title In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani en_US
dc.type Article en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search Digital Repository


My Account