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Oral hypoglygaemic activity of Ipomea aquatica in streptozotocin induced diabetic wistar rats and type II diabetics

Show simple item record Malalavidhane, T.S. en_US Wickremasinghe, S.M.D.N. en_US Perera, M.S.A. en_US Jansz, E.R. en_US 2014-10-29T09:21:52Z 2014-10-29T09:21:52Z 2003 en_US
dc.identifier.citation Phytotherapy Research. 2003; 17(9): pp.1098-1100 en_US
dc.identifier.issn 0951-418X (Print) en_US
dc.identifier.issn 1099-1573 (Electronic) en_US
dc.description Indexed in MEDLINE
dc.description.abstract Ipomoea aquatica Forsk is a common green leafy vegetable consumed in many parts of the world. The present study was designed to investigate theoral hypoglycaemic activity of Ipomea aquatica in streptozotocin induced diabetic Wistar rats, and Type II diabetic patients. Experimental diabetes was induced with streptozotocin in Wistar rats. The rats were then divided into test and control groups. In addition to the standard feed given to both groups the test was fed with the shredded leaves of Ipomoea aquatica (3.4 g/kg) for one week. Type II diabetic patients were subjected to a glucose challenge before and after a single dose of blended I. aquatica. Patients acted as their own controls. The results revealed that consumption of the shredded, fresh, edible portion of I. aquatica for one week, effectively reduced the fasting blood sugar level of streptozotocin-induced diabetic rats (p = 0.01). When subjected to a glucose challenge, the Type II diabetic subjects showed a significant reduction (p = 0.001) in the serum glucose concentration 2 h after the glucose load. However, it was not significantly reduced at 1 h (p < 0.09) post glucose load. There was a 29.4% decrease in the serum glucose concentration of the diabetic patients when treated with the plant extract. en_US
dc.publisher Wiley en_US
dc.subject Blood Glucose-drug effects
dc.subject Diabetes Mellitus, Experimental
dc.subject Diabetes Mellitus, Experimental-drug therapy
dc.subject Diabetes Mellitus, Type 2-drug therapy
dc.subject Hypoglycemic Agents
dc.subject Hypoglycemic Agents-pharmacology
dc.subject Hypoglycemic Agents-therapeutic use
dc.subject Ipomoea
dc.subject Phytotherapy
dc.subject Plant Extracts
dc.subject Plant Extracts-pharmacology
dc.subject Plant Extracts-therapeutic use
dc.title Oral hypoglygaemic activity of Ipomea aquatica in streptozotocin induced diabetic wistar rats and type II diabetics en_US
dc.type Article en_US
dc.identifier.department Biochemistry en_US

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