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Expansion of unconventional T cells with natural killer markers in malaria patients

Show simple item record Watanabe, H. en_US Weerasinghe, A. en_US Miyaji, C. en_US Sekikawa, H. en_US Toyabe, S. en_US Mannor, M.K. en_US Morshed, S.R. en_US Halder, R.C. en_US Kobayashi, J. en_US Toma, H. en_US Sato, Y. en_US Iwai, K. en_US Matsuoka, H. en_US Abo, T. en_US 2014-10-29T09:21:46Z 2014-10-29T09:21:46Z 2003 en_US
dc.identifier.citation Parasitology International. 2003; 52(1): pp.61-70. en_US
dc.identifier.issn 1383-5769 (Print) en_US
dc.identifier.issn 1873-0329 (Electronic) en_US
dc.description Indexed in MEDLINE
dc.description.abstract Immunological states during human malarial infection were examined. In parallel with parasitemia and anemia, granulocytosis was induced in the blood of patients, especially those infected with Plasmodium (P.) falciparum. At that time, the level of lymphocytes remained unchanged or slightly increased in the blood. However, the distribution of lymphocyte subsets was modulated, showing that the proportion of CD56(+)T cells, CD57(+)Tcells, and gammadeltaT cells (i.e. all unconventional T cells) had increased in patients infected with P. falciparum or P. vivax. This phenomenon occurred at the early phase of infection and disappeared in the course of recovery. The data from patients with multiple attacks of P. vivax infection showed that there was no augmentation of these responses. In adult cases, the increase in the proportion of unconventional T cells seemed to closely parallel disease severity. However, all these responses were weak in children, even those infected with P. falciparum. In conjunction with accumulating evidence from mouse malaria experiments, the present results suggest that the immunological state induced by malarial infection might mainly be an event of unconventional T cells and that the immunological memory might not be long-lasting, possibly due to the properties ofunconventional T cells. en_US
dc.publisher Elsevier en_US
dc.subject Malaria en_US
dc.subject Killer Cells, Natural-immunology en_US
dc.subject Malaria, Falciparum-immunology en_US
dc.subject T-Lymphocytes-immunology en_US
dc.subject Malaria, Vivax-immunology en_US
dc.subject Lymphocyte Activation en_US
dc.title Expansion of unconventional T cells with natural killer markers in malaria patients en_US
dc.type Article en_US
dc.identifier.department Physiology en_US
dc.creator.corporateauthor Nihon Kiseichu Gakkai en_US

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