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Impact of mass chemotherapy on the morbidity due to soil-transmitted nematodes

Show simple item record de Silva, N.R. en_US 2014-10-29T09:21:36Z 2014-10-29T09:21:36Z 2003 en_US
dc.identifier.citation Acta Tropica. 2003; 86(2-3): pp.197-214 en_US
dc.identifier.issn 0001-706X (Print) en_US
dc.identifier.issn 1873-6254 (Electronic) en_US
dc.description Indexed in MEDLINE
dc.description.abstract This review summarises current knowledge of the ill-effects of soil-transmitted helminthiasis and takes a detailed look at studies that have been published over the past decade describing the effect of mass anthelminthic use on the health of endemic communities. Mass chemotherapy appears to give maximal returns in terms of improved health in areas where hookworm is a major problem and albendazole is used regularly, along with iron supplements; in children it improves physical growth and iron stores, and in pregnant women it reduces the prevalence of iron-deficiency anaemia. In areas where ascariasis is common, the directly attributable benefits of chemotherapy may be minimal, but it can facilitate the entry of other health care programmes in children, because deworming for ascariasis is often much desired and appreciated by the community. In areas with Vitamin A deficiency and endemic ascariasis, Vitamin A supplementation can be combined with deworming: anthelminthics do not impair Vitamin A absorption but the worms may interfere with Vitamin A uptake by reducing fat absorption. Where trichuriasis is a major problem, single dose chemotherapy may take some time to reduce prevalence, but reduction of heavy infections will reduce the incidence of Trichuris Dysentery Syndrome, probably benefit the learning abilities of affected schoolchildren, and may reduce anaemia and stunting. In general, children should be treated as early as possible, and in areas of very high prevalence, thrice-yearly mass chemotherapy probably improves health better than twice-yearly treatment. en_US
dc.publisher Elsevier en_US
dc.subject Anthelmintics-therapeutic use en_US
dc.subject Nematode Infections-epidemiology en_US
dc.subject Nematode Infections-prevention and control en_US
dc.subject Soil-parasitology en_US
dc.subject Anthelmintics en_US
dc.subject Prevalence en_US
dc.title Impact of mass chemotherapy on the morbidity due to soil-transmitted nematodes en_US
dc.type Review en_US
dc.identifier.department Parasitology en_US

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