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In-vitro studies on the immunomodulatory effects of extracts of Osbeckia aspera

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dc.contributor.author Nicholl, D.S. en_US
dc.contributor.author Daniels, H.M. en_US
dc.contributor.author Thabrew, M.I. en_US
dc.contributor.author Grayer, R.J. en_US
dc.contributor.author Simmonds, M.S.J. en_US
dc.contributor.author Hughes, R.S. en_US
dc.date.accessioned 2014-10-29T09:19:05Z
dc.date.available 2014-10-29T09:19:05Z
dc.date.issued 2001 en_US
dc.identifier.citation Journal of Ethnopharmacology. 2001; 78(1): 39-44 en_US
dc.identifier.issn 0378-8741 (Print) en_US
dc.identifier.issn 1872-7573 (Electronic) en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/1474
dc.description.abstract Ayruvedic medical practitioners in Sri Lanka use aqueous extracts of the mature leaves of Osbeckia aspera to treat liver disease. The extract has been shown to have hepatoprotective effects in vitro and in vivo, and to have inhibitory effects on the complement system and on in vitro phagocytosis by polymorphonuclear cells. The aim of this study was to investigate the effect of an aqueous extract of Osbeckia on lymphocyte proliferation stimulated by mitogens and antigen. In control peripheral blood mononuclear cells (PBMC), high concentrations of the Osbeckia extract were inhibitory to proliferation stimulated by phytohaemagglutinin (PHA) and tuberculin purified protein derivative (PPD). On stimulation by phorbol myristate acetate and ionomycin (PMA+I) the extract showed stimulation of proliferation at low concentrations (<10 microg/ml) with inhibition at higher concentrations. A similar inhibitory pattern on mitogen/antigen stimulation was seen with PBMC from patients with chronic hepatitis C virus (HCV) infection. These results suggest that the inhibitory agent(s) in the aqueous extract of Osbeckia may have an effect on antigen-presenting cell function. The combined hepatoprotective and immunosuppressive effects of the extract are more likely to be beneficial in acute hepatitis rather than chronic hepatitis viral infection. en_US
dc.publisher Elsevier en_US
dc.subject Adjuvants, Immunologic-pharmacology en
dc.subject Hepatitis C, Chronic
dc.subject Hepatitis C, Chronic-immunology
dc.subject Hepatitis C, Chronic-pathology
dc.subject Lymphocytes-drug effects en
dc.subject Mitogens-pharmacology Hepatitis C, Chronic / pathologyracts / pharmacology Plants, Medicinal / chemistry*
dc.subject Plant Extracts
dc.subject Plant Extracts-pharmacology
dc.subject Plants, Medicinal en
dc.subject Plants, Medicinal-chemistry en
dc.title In-vitro studies on the immunomodulatory effects of extracts of Osbeckia aspera en_US
dc.type Article en_US
dc.identifier.department Biochemistry en_US
dc.creator.corporateauthor International Society for Ethnopharmacology en_US


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