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Association between road accidents and low-grade hepatic encephalopathy among Sri Lankan drivers with cirrhosis: a prospective case control study

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dc.contributor.author Subasinghe, S.K.C.E. en_US
dc.contributor.author Nandimuni, Y. en_US
dc.contributor.author Ranasinghe, S. en_US
dc.contributor.author Niriella, M.A. en_US
dc.contributor.author Miththinda, J.K.N.D. en_US
dc.contributor.author Dassanayake, A. en_US
dc.contributor.author de Silva, A.P. en_US
dc.contributor.author de Silva, H.J. en_US
dc.date.accessioned 2016-06-15T06:32:12Z en_US
dc.date.available 2016-06-15T06:32:12Z en_US
dc.date.issued 2016 en_US
dc.identifier.citation BMC Research Notes. 2016; 9(1): 303 en_US
dc.identifier.issn 1756-0500 (Electronic) en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/13519 en_US
dc.description Indexed in MEDLINE en_US
dc.description.abstract BACKGROUND: Low-grade hepatic encephalopathy (LGHE) comprises minimal hepatic encephalopathy (MHE) and grade 1 hepatic encephalopathy. LGHE has no or minimal recognizable symptoms but has mild cognitive and psychomotor deficits. Studies in Western countries have demonstrated increased road accidents (RA) among patients with MHE. Our objective was to investigate the association between Sri Lankan LGHE phenotype and RA. STUDY DESIGN AND METHODS: A prospective, case–control study was conducted in the University Medical Unit, North Colombo Teaching Hospital, Ragama Sri Lanka. Patients with cirrhosis of any aetiology, without OHE, who had been driving during previous 1 month were included. A similar number of age matched, healthy control drivers were also enrolled. Both groups were subjected to five pencil-paper based psychometric tests used to detect LGHE in cirrhotics. Self-reported RA during the previous 1 month were recorded: categorized as ‘major’ when resulted in hospitalization of the involved, ‘minor’ when there were injuries, but not serious enough for hospitalization of the involved and ‘other’ when limited to damages to vehicle or environment without injuries. RESULTS: Among 55 drivers with cirrhosis and LGHE [males, median age 53 years (range 30–60)], 7 (12.7 %) reported RA compared to 6 (10.9 %) among 55 controls [males; median age 51 years (range 30–60)]. There were no ‘major’ accidents in either group. 2/55 (3.6 %) cases and 2/55 (3.6 %) controls reported ‘minor’ accidents. CONCLUSION: There was no increased frequency of RA among Sri Lankan drivers with LGHE compared to healthy controls. This is with the limitation of the study based only on self reported RA. en_US
dc.language.iso en_US en_US
dc.publisher Biomed Central en_US
dc.subject Accidents en_US
dc.subject.mesh Accidents-statistics & numerical data en
dc.subject.mesh Automobile Driving en
dc.subject.mesh Automobile Driving-statistics & numerical data en
dc.subject.mesh Hepatic Encephalopathy en
dc.subject.mesh Hepatic Encephalopathy-complications en_US
dc.subject.mesh Hepatic Encephalopathy-pathology en_US
dc.subject.mesh Liver Cirrhosis en_US
dc.subject.mesh Liver Cirrhosis-complications en_US
dc.subject.mesh Case-Control Studies en_US
dc.subject.mesh Prospective Studies en_US
dc.subject.mesh Psychometrics en_US
dc.subject.mesh Surveys and Questionnaires en
dc.title Association between road accidents and low-grade hepatic encephalopathy among Sri Lankan drivers with cirrhosis: a prospective case control study en_US
dc.type Article en_US


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