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Browsing Journal/Magazine Articles by Author "Jewell, D.P."

Browsing Journal/Magazine Articles by Author "Jewell, D.P."

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  • Acute inflammation in ideal pouches(pouchitis) 
    de Silva, H.J.; Kettlewell, M.; Mortensen, N.J.; Jewell, D.P. (Lippincott Williams And Wilkins, 1991)
  • The Association of autoimmune disorders with inflammatory bowel disease 
    Snook, J.A.; de Silva, H.J.; Jewell, D.P. (Oxford University Press, 1989)
    Medical records of patients with ulcerative colitis (n = 858), Crohn's disease (n = 378) and coeliac disease (n = 148) were examined to determine the prevalence of associated autoimmune disorders. Of outpatient controls ...
  • Clinical and functional outcome after restorative proctocolectomy 
    de Silva, H.J.; de Angelis, C.P.; Soper, N.; Kettlewell, M.G.; Mortensen, N.J.; Jewell, D.P. (1991)
    Restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA) has been carried out on 88 patients since 1982. Three different pouch designs (J, S and W) were used. Ten pouches had to be removed. Detailed analysis was ...
  • Crypt cell proliferation and HLA-DR expression in pelvic ileal pouches 
    de Silva, H.J.; Gatter, K.C.; Millard, P.R.; Kettlewell, M.; Mortensen, N.J.; Jewell, D.P. (BMJ Publishing Group, 1990)
    To investigate the nature of the morphological changes that occur in ileal pouches, 26 biopsy specimens from patients with functioning ileo-anal pouches (eight with pouchitis) were studied. Normal ileum (n = 10) was used ...
  • Cytokine production by human colonic intraepithelial lymphocytes in controls and ulcerative colitis 
    Hoang, P.; Dalton, H.R.; de Silva, H.J.; Jewell, D.P. (Hindawi Publishing Cooperation, 1994)
    Using an ELISA technique, concentrations of gamma-interferon and interleukin-2 were assayed in the supernatants of colonic intraepithelial lymphocytes cultured with or without phytohaemagglutinin (PHA). IntraepitheHal ...
  • Effects of the faecal stream and stasis on the ileal pouch mucosa 
    de Silva, H.J.; Millard, P.R.; Soper, N.; Kettlewell, M.; Mortensen, N.; Jewell, D.P. (British Medical Assosiation, 1991)
    This study aimed to investigate the effects of the faecal stream and stasis on the mucosa of ileal pouches. Nine patients were followed up. Two pouch biopsy specimens were obtained from each at the time of pouch formation, ...
  • Emergence of inflammatory bowel disease 'beyond the West': do prosperity and improved hygiene have a role? 
    de Silva, H.J.; de Silva, N.R.; de Silva, A.P.; Jewell, D.P. (Oxford University Press, 2008)
    Inflammatory bowel disease (IBD) is increasing in many countries 'beyond the West'. This increase may be due to an increased rate of diagnosis but might also represent a true increase in incidence. Economic development, ...
  • Eosinophilic granulomatous vasculitis mimicking a gastric neoplasmn 
    Premaratna, R.; Saparamadu, A.; Samarasekera, D.N.; Warren, B.; Jewell, D.P.; de Silva, H.J. (Blackwell Scientific Publications, 1999)
    No Abstract available
  • Immune activation during cerebellar dysfunction following Plasmodium falciparum malaria 
    de Silva, H.J.; Hoang, P.; Dalton, H.; de Silva, N.R.; Jewell, D.P.; Peiris, J.B. (Oxford University Press, 1992)
    Evidence for immune activation was investigated in 12 patients with a rare syndrome of self-limiting, delayed onset cerebellar dysfunction following an attack of falciparum malaria which occurred 18-26 d previously. ...
  • Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors 
    van Heel, D.A.; Udalova, I.A.; de Silva, A.P.; McGovern, D.P.; Kinouchi, Y.; Hull, J.; Lench, N.J.; Cardon, L.R.; Carey, A.H.; Jewell, D.P.; Kwiatkowski, D. (Oxford University Press, 2002)
    Tumour necrosis factor-alpha (TNF) expression is increased in inflammatory bowel disease (IBD), and TNF maps to the IBD3 susceptibility locus. Transmission disequilibrium and case-control analyses, in two independent ...
  • Lymphocyte and macrophage subpopulations in pelvic ileal pouches 
    de Silva, H.J.; Jones, M.; Prince, C.; Kettlewell, M.; Mortensen, N.J.; Jewell, D.P. (British Medical Assosiation, 1991)
    This study aimed to characterise the mucosal cellular infiltrate in ileal reservoirs with and without pouchitis (reservoir ileitis). Intraepithelial lymphocyte counts were performed in biopsy specimens obtained from ileal ...
  • The Molecular classification of the clinical manifestations of Crohn's Disease. 
    Ahamad, T.; Armuzzi, A.; Bunce, M.; Mulcahy-Hawes, K.; Marshall, S.E.; Orchard, T.R.; Crawshaw, J.; Large, O.; de Silva, A.; Cook, J.T.; Barnardo, M.; Cullen, S.; Welsh, K.I.; Jewell, D.P. (Elsevier-W.B. Saunders, 2002)
    BACKGROUND & AIMS: Crohn's disease is a common inflammatory disorder of the gut characterized by variation in both location and behavior. Chromosome 16 and the HLA region on chromosome 6 have been implicated in susceptibility ...
  • Mucosal characteristics of pelvic ileal pouches 
    de Silva, H.J.; Millard, P.R.; Kettlewell, M.; Mortensen, N.J.; Prince, C.; Jewell, D.P. (British Medical Assosiation, 1991)
    This study aimed to investigate the degree of colonic metaplasia in ileo - anal pouches. Biopsy specimens from 25 patients with functioning pouches, eight of whom had pouchitis, were studied using routine histology, mucosal ...
  • Optimum dose of olsalazine for maintaining remission in ulcerative colitis 
    Travis, S.P.L.; Tysk, C.; de Silva, H.J.; Sandberg-Gertzen, H.; Jewell, D.P.; Jarnerot, G. (British Medical Assosiation, 1994)
    To evaluate the optimum dose of olsalazine for maintaining remission in ulcerative colitis, 198 patients in remission for more than three months were randomly assigned to receive 0.5 g, 1.0 g, or 2.0 g/day for 12 months. ...
  • Short-chain fatty acid irrigation in severe pouchitis 
    de Silva, H.J.; Ireland, A.; Kettlewell, M.; Mortensen, N.; Jewell, D.P. (Massachusetts Medical Society, 1989)
    No Abstract available
  • Subclinical mucosal inflammation in diarrhea-predominant irritable bowel syndrome (IBS) in a tropical setting 
    de Silva, A.P.; Nandasiri, S.D.; Hewavisenthi, J.; Manamperi, A.; Ariyasinghe, M.P.; Dassanayake, A.S.; Jewell, D.P.; de Silva, H.J. (Informa Healthcare, 2012)
    BACKGROUND AND AIMS: There is evidence for low-grade inflammation in the pathophysiology of post-infectious irritable bowel syndrome (IBS). We assessed the degree of subclinical intestinal mucosal inflammation in ...

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