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Browsing Journal/Magazine Articles by Author "Darshana, T."

Browsing Journal/Magazine Articles by Author "Darshana, T."

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  • Hydroxyurea and blood transfusion therapy for Sickle cell disease in South Asia: inconsistent treatment of a neglected disease 
    Darshana, T.; Rees, D.; Premawardhena, A. (BioMed Central, 2021)
    BACKGROUND: Hydroxyurea and blood transfusion therapies remain the main therapeutic strategies for Sickle cell disease. Preliminary data suggest substantial variation and inconsistencies in practice of these two therapeutic ...
  • Oxidative status in the β-thalassemia syndromes in Sri Lanka; a cross-sectional survey 
    Allen, A.; Perera, S.; Mettananda, S.; Rodrigo, R.; Perera, L.; Darshana, T.; Moggach, F.; Crawford, A.J.; Heirene, L.; Fisher, C.; Olivieri, N.; Rees, D.; Premawardhena, A.; Allen, S. (Elsevier Science-Pergamon Press, 2021)
    ABSTRACT: In the β-thalassemias, oxidative stress, resulting from chronic hemolysis, globin chain imbalance, iron overload and depleted antioxidant defences, likely contributes to cell death, organ damage, anemia, hypoxia ...
  • Pyrexia of unknown origin (PUO) and the cost of care in a tertiary care institute in Sri Lanka 
    Premathilaka, R.; Darshana, T.; Ekanayake, C.; Chathurangani, K.C.; Mendis, I.; Perinparajah, S.; Shashiprabha, M.; Nishshanka, S.; Tilakaratna, Y.; Premawardhena, A. (BioMed Central, 2023)
    BACKGROUND: Despite advancements in diagnostic technology, pyrexia of unknown origin (PUO) remains a clinical concern. Insufficient information is available regarding the cost of care for the management of PUO in the South ...
  • Sickle cell disease in Sri Lanka: clinical and molecular basis and the unanswered questions about disease severity 
    Darshana, T.; Bandara, D.; Nawarathne, U.; de Silva, U.; Costa, Y.; Pushpakumara, K.; Pathirage, S.; Basnayake, S.; Epa, C.; Dilrukshi, P.; Wijayawardena, M.; Anthony, A. A.; Rodrigo, R.; Manamperi, A.; Smith, F.; Allen, A.; Menzel, S.; Rees, D.; Premawardhena, A. (BioMed Central., 2020)
    BACKGROUND: Though case reports and limited case series of Sickle cell disease in Sri Lanka have been reported previously, no attempt has been made hitherto to undertake a comprehensive genotypic-phenotypic analysis of ...

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