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Browsing Journal/Magazine Articles by Author "Premawardhena, A.P."

Browsing Journal/Magazine Articles by Author "Premawardhena, A.P."

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  • Natural history of haemoglobin E/beta thalassaemia: the impact of splenectomy on growth and steady state hemoglobin levels 
    Sharma S.; Premawardhena, A.P.; Fathihu, F.; de Silva, S.; de Silva, L.; Vichinsky, E. P.; Weatherall, D. J.; Olivieri, N. F. (American Society of Hematology, 1999)
  • Role of red cell distribution width in screening for Hb Etrait in population ccreening for hemoglobin disorders 
    Nishad, A.A.N.; de Silva, I.S.; Perera, H.L.; Pathmeswaran, A.; Kasturiratne, K.T.A.A.; Premawardhena, A.P. (Lippincott Williams and Wilkins, 2014)
    The national screening policy for hemoglobinopathies uses the cutoffs for red cell indices mean corpuscular volume >80 and mean corpuscular hemoglobin >27, a strategy known to miss some individuals with Hb E trait (EBT), ...
  • Stroke in sickle cell beta thalassemia - a case report highlighting pitfalls in management in a low prevalence country 
    Premathilaka, L.H.R.A.; Lakmini, M.S.; Thamal Dharshana, L.G.; Nawaratne, S.B.; Mettananda, S.; de Silva, S.T.; Premawardhena, A.P. (Kandy Society of Medicine, 2017)
    Stroke in Sickle cell disease is a devastating complication. As Sickle cell disease is uncommon in Sri Lanka many clinicians may be unfamiliar with management of the disease and its complications. A 10-year-old boy presented ...
  • Stroke subtypes in Sri Lanka - a hospital based study 
    Gunatilake, S.B.; Jayasekera, B.A.S.; Premawardhena, A.P. (Sri Lanka Medical Association, 2001)
    AIM: Data on stroke subtypes in Sri Lanka are limited, mainly due to the unavailability of brain imaging facilities in most government hospitals. In two leading private hospitals in Colombo, a high proportion of stroke ...
  • Survival and complications in patients with haemoglobin E thalassaemia in Sri Lanka: a prospective, longitudinal cohort study. 
    Premawardhena, A.P.; Ediriweera, D.S.; Sabouhanian, A.; Allen, A.; Rees, D.; de Silva, S.; Perera, W.; Katugaha, N.; Arambepola, M.; Yamashita, R.C.; Mettananda, S.; Jiffry, N.; Mehta, V.; Cader, R.; Bandara, D.; St Pierre, T.; Muraca, G.; Fisher, C.; Kirubarajan, A.; Khan, S.; Allen, S.; Lamabadusuriya, S.P.; Weatherall, D.J.; Olivieri, N.F. (Elsevier Ltd, 2022)
    Background: Worldwide, haemoglobin E β-thalassaemia is the most common genotype of severe β-thalassaemia. The paucity of long-term data for this form of thalassaemia makes evidence-based management challenging. We did a ...
  • Thalassaemia in Sri Lanka: implications for the future health burden of asian populations 
    de Silva, S.; Fisher, C.A.; Premawardhena, A.P.; Lamabadusuriya, S.P.; Peto, T.E.; Perera, G.; Old, J.M.; Clegg, J.B.; Olivieri, N.F.; Weatherall, D.J.; Sri Lanka Thalassaemia Study Group (Lancet Publishing Group, 2000)
    BACKGROUND: Thalassaemias pose an increasing problem for the Indian subcontinent and many Asian countries. We analysed the different types of thalassaemia in the Sri Lankan population, surveyed gene frequencies in ...
  • Thalassemia in Sri Lanka 
    Premawardhena, A.P.; Madushanka, H.D.P. (Informa Healthcare,London, 2022)
    The island nation of Sri Lanka with 22 million people (in 2020) has an estimated 2000 patients with severe thalassemia. The majority have β-thalassemia (β-thal) major (β-TM), and Hb E (HBB: c.79G>A)/β-thal accounts for ...
  • Thalassemia in Sri Lanka: a progress report 
    Premawardhena, A.P.; de Silva, S.; Arambepola, M.; Olivieri, N.; Merson, L.; Muraco, J.; Allen, A.; Fisher, C.A.; Peto, T.; Vichinsky, E.; Weatherall, D.J. (Oxford University Press, 2004)
    The thalassemias pose an increasing burden for health-care services in many Asian countries. In order to conserve rare resources, it is essential to determine the reasons for the remarkable phenotypic heterogeneity and ...
  • Transfusion-transmitted Hepatitis C: A cluster of cases in transfusion-dependent Thalassaemia patients in Sri Lanka 
    Perera, S.; Bonsall, D.; Niriella, M.A.; Allen, A.; Peries, A.C.; Nelumdeniya, U.B.; Dissanayake, R.; Silva, I.; de Cesare, M.; Klenerman, P.; Weatherall, D.J.; Roberts, D. J.; Premawardhena, A.P. (Blackwell Scientific Publications,, 2020)
    OBJECTIVES: To report the clinical and virologic epidemiology of a recent epidemic of hepatitis C in thalassaemia patients in Sri Lanka. BACKGROUND: Transfusion-dependent thalassaemia patients remain at risk for hepatitis ...
  • A woman with unilateral thigh pain, moderate leukocytosis and extreme thrombocytosis (Case report 2) 
    Dilhani, M.N.; Jayaweera, W.M.N.M.; Williams, H.S.A.; Premawardhena, A.P. (The Sri Lanka College of Haematologists, 2019)
    ABSTRACT: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm (MPN) of hematopoietic stem cells characterized by the presence of the Philadelphia (Ph) chromosome (t (9;22) (q34.1;qll.2), in which granulocytes ...

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