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Clinical management of agrochemical poisoning – promising outcome with evidence based practice

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dc.contributor.author Jayamanne, S.F.
dc.date.accessioned 2016-04-26T11:22:30Z
dc.date.available 2016-04-26T11:22:30Z
dc.date.issued 2016
dc.identifier.citation Proceedings of the 25th Anniversary International Scientific Conference. Faculty of Medicine, University of Kelaniya; 2016: 55 en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/12803
dc.description Symposium G (SYM G): Poisoning and Pollution - 25th Anniversary International Scientific Conference, 6-8 April 2016, Faculty of Medicine,University of Kelaniya, Sri Lanka en_US
dc.description.abstract Pesticide self-poisoning is an important clinical problem in rural regions of the developing world, and kills an estimated 200 000 people every year. It is a major problem in countries like ours where highly toxic organophosphate pesticides and paraquat are available. Medical management is difficult, with case fatality more than 15%. In the early part of this century, little clinical research and evidence existed with which to determine best therapy. Research conducted in Sri Lanka over the last fifteen years has changed the overall management and outcomes. Our main concern is still organophosphates and carbamates. We still do not know how the core treatments—atropine, oximes, should best be given. However, consensus suggests that early resuscitation with atropine, oxygen, respiratory support, and fluids, improve oxygen delivery to tissues, and therefore the final outcome. The role of oximes is not completely clear. Small studies suggest benefit from new treatments such as clonidine, but much larger trials are needed. Gastric lavage could have a role but should only be undertaken once the patient is stable. Some pesticides might prove very difficult to treat with current therapies, such that bans on particular pesticides could be the only method to substantially reduce the case fatality and we have successfully achieved this. en_US
dc.language.iso en_US en_US
dc.publisher Faculty of Medicine, University of Kelaniya, Sri Lanka en_US
dc.subject poisoning en_US
dc.title Clinical management of agrochemical poisoning – promising outcome with evidence based practice en_US
dc.type Article en_US


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