dc.contributor.author |
Wijesooriya, W.R.P.L.I. |
|
dc.contributor.author |
Kotsanas, D.N. |
|
dc.contributor.author |
Korman, T.M. |
|
dc.contributor.author |
Graham, M. |
|
dc.date.accessioned |
2017-07-06T07:16:01Z |
|
dc.date.available |
2017-07-06T07:16:01Z |
|
dc.date.issued |
2017 |
|
dc.identifier.citation |
Sri Lankan Journal of Infectious Diseases. 2017; 7(1): 10 –17 |
en_US |
dc.identifier.issn |
2448-9654(Electronic) |
|
dc.identifier.uri |
http://repository.kln.ac.lk/handle/123456789/127 |
|
dc.description.abstract |
INTRODUCTION AND OBJECTIVES: Coagulase-negative staphylococci (CoNS) are relatively low in virulence but some are increasingly recognized as agents of clinically important infections. Glycopeptides are the drugs of choice for treatment of methicillin-resistant CoNS infections. Our aim was to analyse the susceptibility profile of CoNS in our healthcare network from 2010-2012. METHODS: All CoNS with susceptibility results were analysed as two groups; teicoplanin-susceptible (Teico-S) and non–susceptible (Teico-NS). Analysis included results of other antistaphylococcal antibiotic susceptibilities, sample type (sterile, non-sterile), species and patient location (intensive care unit (ICU) vs non-ICU). RESULTS: Of the 1510 CoNS isolates with susceptibility results, 109 (7.2%) were non-susceptible to teicoplanin. Teicoplanin non-susceptibility was associated with non-susceptibility to ≥ 3 antistaphylococcal-antibiotics, detected more frequently from sterile samples compared to non-sterile samples and from ICU compared to ward patients. Staphylococcus epidermidis was the most common species recovered and was more likely to be Teico-NS. CONCLUSIONS: Teicoplanin non-susceptibility is associated with multi-resistance to ≥3 antistaphylococcal antibiotics. Clinicians should be aware that vancomycin resistance may be selected from Teico-NS strains. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.publisher |
Sri Lankan Society for Microbiology |
en_US |
dc.subject |
Coagulase-negative staphylococci |
en_US |
dc.title |
Teicoplanin non-susceptible coagulase-negative staphylococci in a large Australian healthcare network: Implications for treatment with vancomycin |
en_US |
dc.type |
Article |
en_US |