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Protective effect of vitamin E in kidney storage solution on renal tissue metabolism in rats

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dc.contributor.author Selliah, S. en_US
dc.contributor.author de Mel, T. en_US
dc.contributor.author Hewamadduma, C.A.A. en_US
dc.contributor.author de Tissera, A. en_US
dc.date.accessioned 2014-10-29T09:14:33Z
dc.date.available 2014-10-29T09:14:33Z
dc.date.issued 1995 en_US
dc.identifier.citation The Ceylon Medical Journal. 1995; 40(2): pp.97-100 en_US
dc.identifier.issn 0009-0875 (Print) en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/1252
dc.description Indexed in MEDLINE
dc.description.abstract OBJECTIVE:To determine whether inclusion of vitamin E into kidney storage solutions protects metabolism and tubular ultrastructure of stored rat kidney. METHODS: Rat kidneys were flush stored in Marshall's Citrate (MC) and MC + vitamin E (25% of LD 50 and 50% of LD 50) for 24 hours at 0 degrees C. After storage kidney slices were tested for gluconeogenesis and lactate dehydrogenase (LDH) activity, and examined for cellular ultrastructure. RESULTS: Kidneys stored in MC + vitamin E gave higher gluconeogenesis than those stored in MC alone (p < 0.001). Tubular ultrastructure was better preserved in the presence of Vitamin E. CONCLUSIONS: Vitamin E appears to protect the metabolism and ultrastructure of stored rat kidneys.
dc.publisher Sri Lanka Medical Association en_US
dc.subject Gluconeogenesis-drug effects
dc.subject Kidney-metabolism
dc.subject Organ Preservation
dc.subject Vitamin E-pharmacology
dc.title Protective effect of vitamin E in kidney storage solution on renal tissue metabolism in rats en_US
dc.type Article en_US
dc.identifier.department Physiology en_US
dc.creator.corporateauthor Sri Lanka Medical Association en_US


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