dc.contributor.author |
Patel, R.T. |
en_US |
dc.contributor.author |
Deen, K.I. |
en_US |
dc.contributor.author |
Youngs, D. |
en_US |
dc.contributor.author |
Warwick, J. |
en_US |
dc.contributor.author |
Keighley, M.R. |
en_US |
dc.date.accessioned |
2014-10-29T09:11:34Z |
|
dc.date.available |
2014-10-29T09:11:34Z |
|
dc.date.issued |
1994 |
en_US |
dc.identifier.citation |
British Journal of Surgery. 1994; 81(9): pp.1306-08 |
en_US |
dc.identifier.issn |
0007-1323 (Print) |
en_US |
dc.identifier.issn |
1365-2168 (Electronic) |
en_US |
dc.identifier.uri |
http://repository.kln.ac.lk/handle/123456789/1220 |
|
dc.description |
Indexed in MEDLINE |
|
dc.description.abstract |
Levels of plasma cytokines and circulating endotoxin were assessed in 41 patients with severe intra-abdominal sepsis. Comparison was made with the Acute Physiology And Chronic Health Evaluation (APACHE) II scoring system. Blood samples were taken within 24 h of onset of the sepsis syndrome and at serial times thereafter. Increased levels of interleukin (IL) 6 (range 50-25,500 pg/ml) were detectable in all patients with sepsis. Eighteen of the 19 deaths were attributable to sepsis and higher levels of IL-6 at the onset of the sepsis syndrome correlated with a poor outcome. The sensitivity of IL-6 concentration in predicting mortality was 86.4 per cent with a specificity of 78.9 per cent and an overall correct classification rate of 82.9 per cent. IL-6 level was a better predictor than APACHE II score (sensitivity 72.7 per cent, specificity 57.9 per cent, correct classification rate 65.9 per cent). Levels of tumour necrosis factor alpha, IL-1 beta and endotoxin did not correlate with mortality rate. Plasma IL-6 concentrations may help in planning future strategies to decrease the mortality rate associated with sepsis. |
en_US |
dc.subject |
Bacterial Infections |
|
dc.subject |
Bacterial Infections-mortality |
|
dc.subject |
Endotoxins-blood |
|
dc.subject |
Interleukin-1-blood |
|
dc.subject |
Interleukin-6-blood |
|
dc.subject |
Risk Factors |
|
dc.subject |
Tumor Necrosis Factor |
|
dc.title |
Interleukin 6 is a prognostic indicator of outcome in severe intra-abdominal sepsis |
en_US |
dc.type |
Article |
en_US |
dc.identifier.department |
Surgery |
en_US |