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Hepatocellular carcinoma in Sri Lanka: Where do we stand?

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dc.contributor.author Siriwardana, R.C. en_US
dc.contributor.author Liyanage, C.A.H.L. en_US
dc.contributor.author Jayatunge, D.S.P. en_US
dc.contributor.author Dassanayake, A. en_US
dc.contributor.author Gunetileke, M.G. en_US
dc.contributor.author Niriella, M.A. en_US
dc.contributor.author Sirigampola, C. en_US
dc.contributor.author Upasena, A. en_US
dc.contributor.author de Silva, H.J. en_US
dc.date.accessioned 2016-02-10T10:13:32Z en_US
dc.date.available 2016-02-10T10:13:32Z en_US
dc.date.issued 2013 en_US
dc.identifier.citation Sri Lanka Medical Association, 126th Anniversary Scientific Medical Congress. 2013; 58 Supplement 1: 29 en_US
dc.identifier.issn 0009-0895 en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/11620 en_US
dc.description Oral Presentation Abstract (OP 45), 126th Anniversary Scientific Medical Congress, Sri Lanka Medical Association, 10th-13th July 2013 Colombo, Sri Lanka en_US
dc.description.abstract INTRODUCTION AND OBJECTIVES:Hepato-cellular carcinoma (HCC) is the sixth commonest cancer worldwide. We studied 105 consecutive patients with HCC in a single tertiary care centre. METHODS: North Colombo Liver Unit maintains a prospective database of HCC since September 2011. There were 105 entries by February 2013. Decision on the best form of treatment was taken at a multidisciplinary meeting. RESULTS: The median age at presentation was 63 years (range 12-79). Patients were predominantly male 93 (87%). Alcohol consumption above the safe limit was reported in 47 (45%). Hepatitis B surface antigen or C antibody was not detected in any of the patients. Background liver cirrhosis was evident in 59 (79%). Forty two (46%) patients had single nodular tumours while in 20 (21%) it was diffusely infiltrating. Portal vein invasion was seen in 22 (20 %). Median alpha-feto protein (AFP) level was 57.25 mg/ml (1.16- 94120 ng/ml; n=72). Twenty four (33%) patients had AFP level > 400u/l. Surgery was performed in 20 (19%), liver transplant in 2 (1.9%), radiofrequency ablation or alcohol ablation in 8 (7.6%), trans arterial chemo embolization (TACE) in 44 (41.9%) and sorafinib was prescribed .in four patients. Overall mean survival was 15 months. In the 'no treatment' group, mean survival was 4 months. Surgery group had a mean survival of 20 months. CONCLUSION: Hepatitis B is not a risk factor for HCC in Sri Lankans. Median survival without treatment is 4 months. en_US
dc.language.iso en_US en_US
dc.publisher Sri Lanka Medical Association en_US
dc.subject Carcinoma, Hepatocellular en_US
dc.title Hepatocellular carcinoma in Sri Lanka: Where do we stand? en_US
dc.type Conference Abstract en_US


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