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Does pralidoxime affect outcome of management in acute organophosphorus poisoning?

Show simple item record de Silva, H.J. en_US Wijewickrema, R. en_US Senanayake, N. en_US 2014-10-29T09:10:26Z 2014-10-29T09:10:26Z 1992 en_US
dc.identifier.citation Lancet. 1992; 339(8802): pp.1136-1138 en_US
dc.identifier.issn 0140-6736 (Print) en_US
dc.identifier.issn 1474-547X (Electronic) en_US
dc.description Indexed in MEDLINE
dc.description.abstract Acute organophosphorus (OP) poisoning is usually treated with atropine plus cholinesterase reactivators such as oximes, but controlled trials to assess the efficacy of oximes in OP poisoning have not been done. A period when the acetyl cholinesterase reactivator pralidoxime chloride was not available in Sri Lanka gave us the opportunity to compare atropine alone for treatment of moderate to severe OP poisoning (21 patients) with atropine plus pralixodime (24 patients). Outcome, as assessed clinically, was similar in the two groups. These results cast doubt on the necessity of cholinesterase reactivators for treatment of acute OP poisoning. en_US
dc.publisher Lancet Publishing Group en_US
dc.subject Poisoning
dc.subject Poisoning-drug therapy
dc.subject Poisoning-epidemiology
dc.subject Poisoning-mortality
dc.subject Organophosphate Poisoning
dc.subject Atropine-therapeutic use
dc.subject Cholinesterase Reactivators-therapeutic use
dc.subject Pralidoxime Compounds-therapeutic use
dc.subject Clinical Trial
dc.subject Controlled Clinical Trial
dc.subject Sri Lanka-epidemiology
dc.title Does pralidoxime affect outcome of management in acute organophosphorus poisoning? en_US
dc.type Article en_US
dc.identifier.department Medicine en_US

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