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Mucosal characteristics of pelvic ileal pouches

Show simple item record de Silva, H.J. en_US Millard, P.R. en_US Kettlewell, M. en_US Mortensen, N.J. en_US Prince, C. en_US Jewell, D.P. en_US 2014-10-29T09:10:17Z 2014-10-29T09:10:17Z 1991 en_US
dc.identifier.citation Gut. 1991; 32(1): pp.61-65 en_US
dc.identifier.issn 0017-5749 (Print) en_US
dc.identifier.issn 1468-3288 (Electronic) en_US
dc.description Indexed in MEDLINE
dc.description.abstract This study aimed to investigate the degree of colonic metaplasia in ileo - anal pouches. Biopsy specimens from 25 patients with functioning pouches, eight of whom had pouchitis, were studied using routine histology, mucosal morphometry, mucin histochemistry, and immunoperoxidase staining with monoclonal antibodies directed towards a 40kD colonic protein and a small bowel specific disaccharidase-sucrase isomaltase. Thirteen patients (including all eight with pouchitis) had subtotal or total villous atrophy and crypt hyperplasia. In this group, nine had colorectal type sulphomucin and the 40kD colonic protein was detected in two. These changes were not observed in patients with less severe villous abnormalities. Sucrase-isomaltase activity was, however, present in all 25 pouch specimens. We conclude that although some ileal pouches acquire certain colonic characteristics, complete colonic metaplasia does not occur.
dc.publisher British Medical Assosiation en_US
dc.subject Ileitis-pathology
dc.subject Ileum-metabolism
dc.subject Ileum-pathology
dc.subject Ileum-surgery
dc.subject Intestinal Mucosa-metabolism
dc.subject Intestinal Mucosa-pathology
dc.subject Adenomatous Polyposis Coli-surgery
dc.subject Anal Canal-surgery
dc.subject Anastomosis, Surgical
dc.subject Colitis, Ulcerative-surgery
dc.subject Colon-surgery
dc.subject Sucrase-Isomaltase Complex-metabolism
dc.title Mucosal characteristics of pelvic ileal pouches en_US
dc.type Article en_US
dc.identifier.department Medicine en_US
dc.creator.corporateauthor British Medical Association en_US
dc.creator.corporateauthor British Society of Gastroenterology en_US

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