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Prevalence of eosinophilic oesophagitis among adult Sri Lankan patients with refractory upper gastrointestinal symptoms: a prospective study

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dc.contributor.author Ranawaka, C.K. en_US
dc.contributor.author de Silva, A.P. en_US
dc.contributor.author de Alwis, R. en_US
dc.contributor.author Waraketiya, P.R. en_US
dc.contributor.author Jayathilake, T.M.A.H. en_US
dc.contributor.author Niriella, M.A. en_US
dc.contributor.author Dassanayake, A.S. en_US
dc.contributor.author Hewavisenthi, S.J.de S. en_US
dc.contributor.author de Silva, H.J. en_US
dc.date.accessioned 2015-12-24T13:40:27Z en_US
dc.date.available 2015-12-24T13:40:27Z en_US
dc.date.issued 2012 en_US
dc.identifier.citation Journal of Gastroenterology and Hepatology. 2012; 27(Supp 5): 315 en_US
dc.identifier.issn 0815-9319 (Print) en_US
dc.identifier.issn 1440-1746 (Electronic) en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/10952 en_US
dc.description Poster Session Abstract (P15-07), 22nd Asian Pacific Digestive Week, December 5–8, 2012, Bangkok, Thailand en_US
dc.description.abstract BACKGROUND AND AIM: Eosinophilic oesophagitis (EoE) is increasing in the West (community prevalence 0.02–1%). It is especially prevalent among patients with refractory upper gastrointestinal (UGI) symptoms (8.8–48%). Diagnosis is important as the treatment is with corticosteroids and other immunomodulators rather than acid suppression and prokinetics. EOE has been poorly studied in Asian populations. Our aim of this study was to evaluate the prevalence of EoE among adult Sri Lankan patients with refractory UGI symptoms. METHODS: The study was carried out in the University Medical Unit, Colombo North Teaching Hospital, Ragama, Sri Lanka. Over a period of one year from March 2011, consecutive, consenting patients (aged 18–70) referred for gastroduodenoscopy (OGD); with persistent UGI symptoms despite standard therapy for at least two months were recruited. Patients without significant abnormalities other than features of EoE on OGD underwent two biopsies each from the distal and mid oesophagus. Biopsies were obtained from duodenum and stomach at the same time to rule out possible eosonophilic gastroenteritis. A diagnosis of EoE was made when there were 15 or more intra-epithelial eosinophils per high-power field, according to the international guidelines. RESULTS AND DISCUSSION: Common refractory symptoms were dyspepsia, gastro-oesophageal refl ux and dysphagia in 74, 64, 27 respectively. Only 106 patients (M: F = 42:64 mean age 48 yrs (SD 13.3) who fulfill the criteria underwent oesophageal biopsies. Endoscopy was macroscopically normal in 98 patients and suggestive of EoE in 8; concentric mucosal rings in 2 and white exudates in 6 patients. Only 2 (1.9%) patients had histological evidence of EoE, both had symptoms of refractory dyphagia and one had compatible macroscopic endoscopic features of EoE (concentric mucosal rings). CONCLUSION: The prevalence of EoE in this Sri Lankan cohort of adult patients with refractory UGI symptoms was much lower than reported in Western series en_US
dc.language.iso en_US en_US
dc.publisher Wiley Blackwell Scientific Publications en_US
dc.subject Eosinophilic Esophagitis en_US
dc.subject Prevalence en_US
dc.subject Prospective Studies en_US
dc.subject Gastrointestinal Diseases en_US
dc.title Prevalence of eosinophilic oesophagitis among adult Sri Lankan patients with refractory upper gastrointestinal symptoms: a prospective study en_US
dc.type Conference Abstract en_US
dc.creator.corporateauthor Asian Pacific Association of Gastroenterology en
dc.creator.corporateauthor Asian Pacific Association for the Study of the Liver en


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