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Synthesis of Fe2O3 nanoparticles for the development of a rapid diagnostic test kit for dengue detection

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dc.contributor.author Jayarathna, I.P.L.
dc.contributor.author Gunathilaka, P.A.D.H.N.
dc.contributor.author Athapaththu, A.M.M.H.
dc.contributor.author Abeyewickreme, W.
dc.date.accessioned 2015-12-18T04:44:27Z
dc.date.available 2015-12-18T04:44:27Z
dc.date.issued 2015
dc.identifier.citation Proceedings of the Current Research Activities on dengue conducted by the Faculty of Medicine, University of Kelaniya, Sri Lanka.2015:16 en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/10891
dc.description Keynote Address en_US
dc.description.abstract BACKGROUND: Hybrid nanoparticles have great potential for biotechnological and biomedical applications. It was recently proposed that biopolymer/co-shell nano-materials could be easily obtained by adapting traditional routes used in pharmaceutical science to design drug delivery system. Most of the case, super-paramagnetic nanoparticles of iron oxides, magnetite (Fe3O4) and maghemite (ᵧ -Fe2O3) have been employed and these interesting magnetic properties are due to finite-size effects and high surface/volume ratio. METHOD: Iron oxide was synthesized by using modified co-precipitation method and resulting particles were characterized using X-ray diffraction (XRD), Transmission Electron Microscopy (TEM) and Diffused Reflectance Fourier Transform-Infrared Spectroscopy (DRIFT-IR). RESULTS: The XRD pattern matches well that of ᵧ -Fe2O3. Six characteristic peaks for ᵧ -Fe2O3 (2θ = 31.7°, 36.7°, 41.1°, 53.4°, 57.0° and 62.6°) marked by their Miller indices [(220), (311), (400), (422), (511) and (440)] were observed for sample. The TEM images reveal that the particles are in 5 – 20 nm range, and well fitted with spaniel cubic structure, but when particles are dry it prefer to agglomerate with neighboring particles to reduce their surface charges. The spectrum of ᵧ -Fe2O3 nanoparticles shows a characteristic broad band at 3410 cm-1 is due to the stretching vibration of H2O molecules. The band corresponding to the bending vibrations of H2O molecules is positioned at 1633 cm-1. Two intense IR bands at 627 and 451 cm-1 are typical for ferrihydrite or ᵧ -Fe2O3 nanoparticles. The spectrum of this sample showed the presence of carbonate groups on the basis of IR bands at 1508, 1340 and 1069 cm-1. The presence of carbonate groups is due to the adsorption of atmospheric carbon dioxide by ᵧ -Fe2O3 nanoparticles. The bands of Fe–O stretching vibrations of ᵧ -Fe2O3 appeared at 627 and 451 cm-1 and the bands at 892 and 796 cm-1 can be assigned to Fe-OH···H bending vibrations. CONCLUSION: Magnetic ᵧ -Fe2O3 nanoparticles were synthesized by the co-precipitation method and this work confirmed that magnetic ᵧ -Fe2O3 nanoparticles are in nano-scale and well matches with spaniel cubic structure en_US
dc.language.iso en_US en_US
dc.publisher Moleclar Medicine Unit, Faculty of Medicine, University of Kelaniya, Sri Lanka en_US
dc.subject Dengue en_US
dc.subject Dengue-Diagnosis en
dc.title Synthesis of Fe2O3 nanoparticles for the development of a rapid diagnostic test kit for dengue detection en_US
dc.type Conference Abstract en_US


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