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Diffuse and nodular type hepatocellular carcinoma - a comparative study

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dc.contributor.author Wickramarathne, S.D.J. en_US
dc.contributor.author Jayarathne, V.S. en_US
dc.contributor.author Siriwardana, R.C. en_US
dc.contributor.author Liyanage, C.A.H. en_US
dc.contributor.author Niriella, M.A. en_US
dc.contributor.author Dassanayake, A.S. en_US
dc.contributor.author Gunetilleke, M.B. en_US
dc.contributor.author de Silva, A.P. en_US
dc.contributor.author de Silva, H.J. en_US
dc.date.accessioned 2015-12-08T08:55:02Z en_US
dc.date.available 2015-12-08T08:55:02Z en_US
dc.date.issued 2015 en_US
dc.identifier.citation Proceedings of the Sri Lanka Medical Association, Anniversary Academic Sessions. 2015; 128: 193 en_US
dc.identifier.uri http://repository.kln.ac.lk/handle/123456789/10643 en_US
dc.description Poster Presentation Abstract (PP64), 128th Annual Scientific Sessions, Sri Lanka Medical Association, 6th-8th July 2015 Colombo, Sri Lanka en_US
dc.description.abstract INTRODUCTION AND OBJECTIVES: Incidence of hepatocellular carcinoma (HCC) is increasing. Diffuse HCC (dHCC) is rare and data on such tumours are limited. METHOD: Ail consenting patients with HCC referred to Colombo North Liver Unit, Ragama (September 2011-February 2014) were Included. Tumours with diffuse margins on imaging were categorized as dHCC, while tumours with clear nodular morphology were categorized as nodular HCC (nHCC). Baseline parameters, treatment options and survival were compared between the two types. RESULTS: 203 HCCs were included in the study [dHCC=41(20%):87.8% males; nHCC=162(80%) 89.5% males]. The median age at presentation in the two groups was similar [dHCC 63.58(47-76) years, nHCC 62.13(12-88) years]. More patients with dHCC had a significant alcohol intake (68.9% vs. 41.7%, p=0.002). Background cirrhosis was present in 90.2% of dHCC compared to 79.1% in nHCC (p<0.05). Aspartate transaminase, Alanine transaminase, INR, total bilirubin, platelet count and MELD scores were similar in the two groups. Median alfa fetoprotein (AFP) was significantly higher in dHCC (136 vs 31ng/mL, p<0.001). Similar typical enhancement pattern on dynamic imaging was noted in the two groups (80.5% dHCC, 84.4% nHCC). dHCC had high incidence of major vascular invasion(78% vs 23.5%, p<0.001). Seventy six point nine percent of dHCC had only palliative care compared to 28.4% in nHCC was two months compared to 8 months in nHCC. CONCLUSION: 1/5 of HCCs were of the diffuse type. Patients dHCC had a significant alcohol intake. They had higher AFP, advanced disease at presentation with more vascular invasion and a worse prognosis than nHCC. en_US
dc.language.iso en_US en_US
dc.publisher Sri lanka Medical Association en_US
dc.subject Carcinoma, Hepatocellular en_US
dc.title Diffuse and nodular type hepatocellular carcinoma - a comparative study en_US
dc.type Conference Abstract en_US


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