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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Show simple item record Kato, N. Loh, M. Takeuchi, F. Verweij, N. Wang, X. Zhang, W. Kelly, T.N. Saleheen, D. Lehne, B. Leach, I.M. Drong, A.W. Abbott, J. Wahl, S. Tan, S.T. Scott, W.R. Campanella, G. Chadeau-Hyam, M. Afzal, U. Ahluwalia, T.S. Bonder, M.J. Chen, P. Dehghan, A. Edwards, T.L. Esko, T. Go, M.J. Harris, S.E. Hartiala, J. Kasela, S. Kasturiratne, A. Khor, C.C. Kleber, M.E. Li, H. Mok, Z.Y. Nakatochi, M. Sapari, N.S. Saxena, R. Stewart, A.F. Stolk, L. Tabara, Y. Teh, A.L. Wu, Y. Wu, J.Y. Zhang, Y. Aits, I. Da Silva Couto Alves, A. Das, S. Dorajoo, R. Hopewell, J.C. Kim, Y.K. Koivula, R.W. Luan, J. Lyytikäinen, L.P. Nguyen, Q.N. Pereira, M.A. Postmus, I. Raitakari, O.T. Bryan, M.S. Scott, R.A. Sorice, R. Tragante, V. Traglia, M. White, J. Yamamoto, K. Zhang, Y. Adair, L.S. Ahmed, A. Akiyama, K. Asif, R. Aung, T. Barroso, I. Bjonnes, A. Braun, T.R. Cai, H. Chang, L.C. Chen, C.H. Cheng, C.Y. Chong, Y.S. Collins, R. Courtney, R. Davies, G. Delgado, G. Do, L.D. Doevendans, P.A. Gansevoort, R.T. Gao, Y.T. Grammer, T.B. Grarup, N. Grewal, J. Gu, D. Wander, G.S. Hartikainen, A.L. Hazen, S.L. He, J. Heng, C.K. Hixson, J.E. Hofman, A. Hsu, C. Huang, W. Husemoen, L.L. Hwang, J.Y. Ichihara, S. Igase, M. Isono, M. Justesen, J.M. Katsuya, T. Kibriya, M.G. Kim, Y.J. Kishimoto, M. Koh, W.P. Kohara, K. Kumari, M. Kwek, K. Lee, N.R. Lee, J. Liao, J. Lieb, W. Liewald, D.C. Matsubara, T. Matsushita, Y. Meitinger, T. Mihailov, E. Milani, L. Mills, R. Mononen, N. Müller-Nurasyid, M. Nabika, T. Nakashima, E. Ng, H.K. Nikus, K. Nutile, T. Ohkubo, T. Ohnaka, K. Parish, S. Paternoster, L. Peng, H. Peters, A. Pham, S.T. Pinidiyapathirage, M.J. Rahman, M. Rakugi, H. Rolandsson, O. Rozario, M.A. Ruggiero, D. Sala, C.F. Sarju, R. Shimokawa, K. Snieder, H. Sparso, T. Spiering, W. Starr, J.M. Stott, D.J. Stram, D.O. Sugiyama, T. Szymczak, S. Tang, W.H. Tong, L. Trompet, S. Turjanmaa, V. Ueshima, H. Uitterlinden, A.G. Umemura, S. Vaarasmaki, M. van Dam, R.M. van Gilst, W.H. van Veldhuisen, D.J. Viikari, J.S. Waldenberger, M. Wang, Y. Wang, A. Wilson, R. Wong, T.Y. Xiang, Y.B. Yamaguchi, S. Ye, X. Young, R.D. Young, T.L. Yuan, J.M. Zhou, X. Asselbergs, F.W. Ciullo, M. Clarke, R. Deloukas, P. Franke, A. Franks, P.W. Franks, S. Friedlander, Y. Gross, M.D. Guo, Z. Hansen, T. Jarvelin, M.R. Jorgensen, T. Jukema, J.W. Kähönen, M. Kajio, H. Kivimaki, M. Lee, J.Y. Lehtimäki, T. Linneberg, A. Miki, T. Pedersen, O. Samani, N.J. Sorensen, T.I. Takayanagi, R. Toniolo, D. BIOS-consortium CARDIo GRAMplusCD LifeLines Cohort Study InterAct Consortium Ahsan, H. Allayee, H. Chen, Y.T. Danesh, J. Deary, I.J. Franco, O.H. Franke, L. Heijman, B.T. Holbrook, J.D. Isaacs, A. Kim, B.J. Lin, X. Liu, J. März, W. Metspalu, A. Mohlke, K.L. Sanghera, D.K. Shu, X.O. van Meurs, J.B. Vithana, E. Wickremasinghe, A.R. Wijmenga, C. Wolffenbuttel, B.H. Yokota, M. Zheng, W. Zhu, D. Vineis, P. Kyrtopoulos, S.A. Kleinjans, J.C. McCarthy, M.I. Soong, R. Gieger, C. Scott, J. Teo, Y.Y. He, J. Elliott, P. Tai, E.S. van der Harst, P. Kooner, J.S. Chambers, J.C. 2015-11-05T10:42:29Z 2015-11-05T10:42:29Z 2015
dc.identifier.citation Nature Genetics.2015;47:1282 - 1293 en_US
dc.identifier.issn 1061-4036 (Print)
dc.identifier.issn 1546-1718 (Electronic)
dc.description Indexed in MEDLINE, SCI, SCI Expanded, BIOSIS Previews en_US
dc.description.abstract We carried out a trans-ancestry genome-wide association and replication study of blood pressurephenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNAmethylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNAmethylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation. en_US
dc.language.iso en_US en_US
dc.publisher Nature Publishing Company en_US
dc.subject genetic loci influencing blood pressure en_US
dc.title Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation en_US
dc.type Article en_US

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